Sort   by:  
 Page size 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsOlive Oil Authenticity Studies by Target and Non-target LC-QTOF-MS combined with Advanced Chemometric Techniques
Food analysis is continuously requesting the development of more robust, efficient and cost-effective food authentication analytical methodologies to guarantee the safety, quality and traceability of food commodities with respect to legislation and consumer demands. Hence, a novel RP-UHPLC-ESI-QTOF-...
2017-05-04 | MTBLS433 | MetaboLights
MetabolomicsA Python-based pipeline for preprocessing LC-MS data for untargeted metabolomics workflows
Preprocessing data in a reproducible and robust way is one of the current challenges in untargeted metabolomics workflows. Data curation in liquid chromatography-mass spectrometry (LC-MS) involves the removal of unwanted features (retention time; m/z pairs) to retain only high-quality data for subse...
2020-11-21 | MTBLS1919 | MetaboLights
MetabolomicsSerum LC-MS metabolomics profiling during musk secretion in captive forest musk deer (Moschus berezovskii)
This study investigates serum metabolomic changes associated with musk secretion in captive male forest musk deer (Moschus berezovskii). Paired serum samples were collected before secretion and during secretion and analyzed using LC-MS in both positive and negative ion modes. The study includes biol...
2026-04-23 | MTBLS14280 | MetaboLights
MetabolomicsHigh-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS.
Plant alkaloids represent a diverse group of nitrogen-containing natural products. These compounds are considered valuable in drug discovery and development. High-throughput identification of such plant secondary metabolites in complex plant extracts is essential for drug discovery, lead optimizatio...
2023-12-12 | MTBLS2914 | MetaboLights
MetabolomicsTroubleshooting in Large-Scale LC-ToF-MS Metabolomics Analysis: Solving Complex Issues in Big Cohorts
Metabolomics, understood as the science that manages the study of compounds from the metabolism, is an essential tool for deciphering metabolic changes in disease. The experiments rely on the use of high-throughput analytical techniques such as liquid chromatography coupled to mass spectrometry (LC-...
2019-12-12 | MTBLS1133 | MetaboLights
MetabolomicsLC-MS-based isotope tracing data supporting cholesterol- and EA2-regulated fatty acid synthesis and tumor metabolic remodeling
This study contains LC-MS-based stable isotope tracing data investigating cholesterol- and EA2-regulated tumor metabolic remodeling. The dataset includes U-13C-glucose tracing in tumor cells and D2O tracing in animal models, supporting analysis of cholesterol-driven metabolic remodeling and the supp...
2026-10-03 | MTBLS14937 | MetaboLights
MetabolomicsMetabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community; Interaction between the kefir isolates Lactococcus lactis and Acetobacter (spent-medium assay, measured untargeted (FIA-qTOF) and targeted (HILIC, LC-MS)

Microbial communities often undergo intricate compositional changes yet also maintain stable coexistence of diverse species. The mechanisms underlying long-term coexistence remain unclear, as system-wide studies have been largely limited to engineered communities, ex situ adapted cultures, or syn...

2020-11-04 | MTBLS1823 | MetaboLights
MetabolomicsFlow cytometry has a significant impact on the cellular metabolome (General LC-MS assay)
The characterization of specialized cell subpopulations in a heterogeneous tissue is essential for understanding organ function in health and disease. A popular method of cell isolation is fluorescence-activated cell sorting (FACS) based on probes that bind surface or intracellular markers. In this ...
2018-11-06 | MTBLS629 | MetaboLights
MetabolomicsFlow cytometry has a significant impact on the cellular metabolome (Lipidomic LC-MS assay)
The characterization of specialized cell subpopulations in a heterogeneous tissue is essential for understanding organ function in health and disease. A popular method of cell isolation is fluorescence-activated cell sorting (FACS) based on probes that bind surface or intracellular markers. In this ...
2018-11-06 | MTBLS631 | MetaboLights
Sort   by:  
 Page size