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ProteomicsA rapid workflow for high-throughput FFPE-based quantitative proteomics
Formalin-fixed, paraffin-embedded (FFPE) tissue samples are an invaluable resource to study the underlying molecular mechanisms of the diseases and when coupled with laser capture microdissection (LCM, isolation of sub histological regions of the tissue sections is readily obtained for further analy...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040727 | Pride
Ffpe Tandem mass spectrometry Kidney Lcm 
TranscriptomicsA laser capture microdissection-based method for high-sensitivity transcriptomics from archived FFPE tissue slides with single-cell resolution using LCM-FFPEseq
Understanding gene expression within its spatial context is essential for unravelling biological processes. Laser Capture Microdissection (LCM) has emerged as a transformative technology, enabling targeted isolation of individual cells or regions from tissue sections while preserving spatial context...
ORGANISM(S): Homo sapiens 
2026-08-29 | GSE305348 | GEO
GenomicsA laser capture microdissection-based method for high-sensitivity transcriptomics from archived FFPE tissue slides with single-cell resolution using LCM-FFPEseq
A laser capture microdissection-based method for high-sensitivity transcriptomics from archived FFPE tissue slides with single-cell resolution using LCM-FFPEseq
PRJNA1305356 | ENA
ProteomicsSpatial proteomics to discover aging-associated alterations in the renal tubulointerstitium
The preservation of tissue architecture and morphology, in formalin-fixed paraffin-embedded (FFPE) tissue enables spatial resolution at the cellular and sub-cellular level. Laser capture microdissection (LCM) combined with liquid chromatography mass spectrometry analysis has enabled the collection o...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD059176 | Pride
Ffpe Lcm Kidney Lc-ms/ms 
ProteomicsLaser-capture proteomics of human FFPE substantia nigra
Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens. In combination with formalin-fixed and paraffin-embedded (FFPE) tissue it provides a powerful tool for retrospective and clinically rele...
ORGANISM(S): Homo sapiens (Human) 
2020-03-05 | PXD016563 | Pride
Laser-capture microdissection Tmt Ffpe Substantia nigra 
TranscriptomicsStromal and epithelial changes in breast cancer following endocrine treatment
Patients diagnosed with breast cancer were recruited to an important trial, the Tamoxifen Window Trial, in two series, series A during 1988-1989 and series B during 1989-1990. Some patients received tamoxifen for short windows. Clinical samples (biopsies) for this trial were collected before and aft...
ORGANISM(S): Homo sapiens 
2014-07-07 | E-GEOD-58598 | biostudies-arrayexpress
TranscriptomicsExome-capture RNAseq of microdissected FFPE human breast cancer cells, cancer-associated fibroblasts, and surrounding tumor-infiltrating lymphocytes
Here we describe the development of a robust method for RNA extraction and exome-capture RNA-sequencing of laser-capture microdissected (LCM) tumor cells (TC) and stromal immune cells (TIL) based on their morphology. We applied this method on seven tumor specimens and microbiopsies of triple-negativ...
ORGANISM(S): Homo sapiens 
2021-10-31 | E-MTAB-8760 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Ameloblastoma using Laser capture microdissection
The goal of the study was to characterize the whole genome transcriptome profiles of pure sample population of human ameloblastoma epithelial cells for examination of molecular pathways. Seventeen human ameloblastoma samples were obtained. Both fresh frozen and FFPE samples were used and placed in s...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-68531 | biostudies-arrayexpress
UnknownQuantitative Profiling of the Human Substantia Nigra Proteome from Laser-capture Microdissected FFPE Tissue.
Not available
S-EPMC7196589 | biostudies-literature
UnknownGene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ.
Not available
S-EPMC6836736 | biostudies-literature
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