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TranscriptomicsGene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.
Lcn2 is involved in host defense against pathogens, but the function in intestinal mucosal immunity and inflammation remains largely unknown. Genetic ablation of Lcn2 results in early-onset colitis and spontaneous emergence of right-sided colonic tumors in the setting of IL-10 deficiency (Lcn2-/-;IL...
ORGANISM(S): Mus musculus 
2016-03-30 | E-MTAB-4583 | biostudies-arrayexpress
TranscriptomicsEffects of Lipocalin 2 (Lcn2), iron, and the bacterial siderophore Enterobactin on A549 respiratory cell gene expression
Iron is essential for many cellular processes and is required by bacteria for replication. To acquire iron from the host, pathogenic Gram-negative bacteria secrete siderophores, including Enterobactin (Ent). However, Ent is bound by the host protein Lipocalin 2 (Lcn2), preventing bacterial reuptake ...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54962 | biostudies-arrayexpress
TranscriptomicsMouse primary astrocytes: LCN2 protein treated vs. control
Transcriptional profiling of mouse primary astrocytes comparing control untreated astrocytes with astrocytes treated with recombinant LCN2 protein (10 micro gram/ml). Goal was to determine the effects of LCN2 treatment on global gene expression in astrocytes. A secreted protein lipocalin-2 (LCN2) ha...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-15667 | biostudies-arrayexpress
GenomicsNext Generation Sequencing of LCN2+/+ and LCN2 -/- MCF7 exposed to conditioned media from senescent fibroblasts
Next Generation Sequencing of LCN2+/+ and LCN2 -/- MCF7 exposed to conditioned media from senescent fibroblasts
PRJNA816458 | ENA
GenomicsEffect of recombinant murine Lipocalin-2 (LCN2) on murine macrophages
Effect of recombinant murine Lipocalin-2 (LCN2) on murine macrophages
PRJNA935307 | ENA
GenomicsLack of tumor-derived LCN2 sensitizes pancreatic cancer cells to ferroptosis induction
Lack of tumor-derived LCN2 sensitizes pancreatic cancer cells to ferroptosis induction
PRJNA1307606 | ENA
GenomicsLcn2 deficiency leads to social impairments independent of maternal immune activation
Lcn2 deficiency leads to social impairments independent of maternal immune activation
PRJNA1294255 | ENA
GenomicsThe protective effect of LCN2 knockout on the imiquimod-induced psoriatic mouse model
The protective effect of LCN2 knockout on the imiquimod-induced psoriatic mouse model
PRJNA1013395 | ENA
TranscriptomicsMouse primary astrocytes: LCN2 protein treated vs. control
Transcriptional profiling of mouse primary astrocytes comparing control untreated astrocytes with astrocytes treated with recombinant LCN2 protein (10 micro gram/ml). Goal was to determine the effects of LCN2 treatment on global gene expression in astrocytes. A secreted protein lipocalin-2 (LCN2) ha...
ORGANISM(S): Mus musculus 
2012-06-30 | GSE15667 | GEO
GenomicsDefective LCN2–FN1 signaling impairs stromal–immune communication and underlies recurrent implantation failure
Defective LCN2–FN1 signaling impairs stromal–immune communication and underlies recurrent implantation failure
PRJNA1296191 | ENA
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