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ProteomicsImpaired stability of tumor cells after targeting of lactate/pyruvate metabolism investigated by shotgun proteomics
Overexpression of heat shock proteins (HSPs), especially the major stress-inducible 72 kDa heat shock protein 70 (Hsp70), in malignant tumor cells is associated with therapeutic resistance. The heightened metabolic demand in tumor cells (Warburg effect) increases lactate dehydrogenase (LDH) activity...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026078 | Pride
Lc-msms Heat shock proteins Lactate/pyruvate metabolism Ldha/b double knockout Membrane hsp70 expression Radiosensitivity 
UnknownWhole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase.
Not available
S-EPMC7472444 | biostudies-literature
UnknownDouble genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
Not available
S-EPMC6187639 | biostudies-literature
UnknownMetabolic Response to the Mitochondrial Toxin 1-Methyl-4-phenylpyridinium (MPP+) in LDH-A/B Double-knockout LS174T Colon Cancer Cells.
Not available
S-EPMC8240042 | biostudies-literature
UnknownTargeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response.
Not available
S-EPMC8345170 | biostudies-literature
UnknownA Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922.
Not available
S-EPMC9022188 | biostudies-literature
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