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TranscriptomicsExpression data from ARPE-19 cells treated with LDL or ox-LDL
LDL or Ox-LDL 200ug/ml, which showed no loss of viability after a 48 hour exposure, induced a physiological and pathological transcriptional response, respectively. LDL induced a downregulation of genes associated with cholesterol biosynthesis while ox-LDL induced transcriptional alterations in gene...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5741 | biostudies-arrayexpress
TranscriptomicsExpression data of human vascular smooth muscle cells (hVSMC) in response to n-LDL and ox-LDL.
Early transcriptomic response to n-LDL and ox-LDL in human vascular smooth muscle cells (hVSMC). We used microarrays with the aim of assessing early molecular changes that induce a response in the VSMC using native and oxidized low-density lipoprotein (n-LDL and ox-LDL). For each LDL internalization...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-68021 | biostudies-arrayexpress
GenomicsTrib1 regulates mouse LDL metabolism through Cebpa-mediated regulation of the LDL receptor in hepatocytes.
Trib1 regulates mouse LDL metabolism through Cebpa-mediated regulation of the LDL receptor in hepatocytes.
PRJNA666639 | ENA
ModelsMcAuley2012 - Whole-body Cholesterol Metabolism
McAuley2012 - Whole-body Cholesterol Metabolism Lipid metabolism has a key role to play in human longevity and healthy aging. A whole-body mathematical model of cholesterol metabolism that explores the changes in both the rate of intestinal cholesterol absorption and the hepatic ra...
2024-09-02 | BIOMD0000000434 | BioModels
ProteomicsApolipoprotein F in hyperlipidemia
Apolipoprotein F (ApoF) modulates lipoprotein metabolism by selectively inhibiting cholesteryl ester transfer protein (CETP) activity on LDL. This ApoF activity requires that it is bound to LDL. How hyperlipidemia alters total plasma ApoF and its binding to LDL are poorly understood. In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD029713 | Pride
Hypercholesterolemia Plasma lipid transfer proteins Hypertriglyceridemia Apolipoproteins Ldl metabolism Lipid biochemistry Apolipoprotein f Cholesteryl ester transfer protein Lipoproteins 
TranscriptomicsGlycemic index differences of high-fat diets modulate primarily lipid metabolism in murine adipose tissue
We previously reported that a low versus high glycemic index (GI) diet on a high fat (30% kcal fat) background (LGI and HGI, respectively) significantly retarded adverse health effects in C57BL/6J male mice. The LGI diet enhanced whole body insulin sensitivity and repressed high fat diet-induced bod...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-26930 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers of C57BL/6 mice and LDL receptor deficient mice fed on either low fat or high fat diet to study liver gene expression associated with diet.
Examination of gene expression profiles from liver of C57BL/6 mice and LDL receptor deficient mice fed on either a low fat diet or a high fat Western-style diet for 12 weeks. Three replicates of each condition analyzed. Keywords = LDL receptor deficiency, high fat diet, atherosclerosis, liver
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-363 | biostudies-arrayexpress
GenomicsImpaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: a role for the LDL receptor and cholesterol metabolism in adult neural precursor cells (LDL treatment)
Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: a role for the LDL receptor and cholesterol metabolism in adult neural precursor cells (LDL treatment)
PRJNA563678 | ENA
UnknownmiRNA regulation of LDL-cholesterol metabolism.
Not available
S-EPMC5375104 | biostudies-literature
GenomicsLDL-stimulated microglial activation exacerbates white matter damage
LDL-stimulated microglial activation exacerbates white matter damage
PRJNA954689 | ENA
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