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MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
TranscriptomicsTranscription profiling of human stimulate neutrophils to investigate the impact of anti-inflammatory agents on the gene expression profiles
Adenosine, prostaglandin E2, or increased intracellular cyclic AMP concentration each elicit potent anti-inflammatory events in human neutrophils by inhibiting functions such as phagocytosis, superoxide production, adhesion and cytokine release. However, the endogenous molecular pathways mediating t...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-14465 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of myeloid cells (neutrophils, macrophages and dendritic cells) isolated from the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE)
We have discovered that neutrophils that infiltrate the spinal cord of mice with EAE, a model of multiple sclerosis, but not intravascular neutrophils that crawl on the luminal endothelial surface, bear on their surface the adhesion molecule Icam1. The goal of this experiment was to use Icam1 to iso...
ORGANISM(S): Mus musculus 
2017-11-10 | E-MTAB-6160 | biostudies-arrayexpress
Unknownde novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia.
Not available
S-EPMC7325098 | biostudies-literature
TranscriptomicsCharacterization of a tetra-culture system combining lung alveolar epithelial cells, endothelial cells, macrophages, and mast cells in a three-dimensional orientation
To more accurately model inhalation toxicity in vitro, we developed a tetra-culture system that combines lung alveolar epithelial cells, endothelial cells, macrophages, and mast cells in a three-dimensional orientation. We characterized the influence of the added complexity, using network perturbati...
ORGANISM(S): Homo sapiens 
2019-02-12 | E-MTAB-7072 | biostudies-arrayexpress
UnknownCharacterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation
Not available
S-SCDT-10_15252-EMBJ_2023113866 | biostudies-other
UnknownWhite blood count, D-dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID-19 patients: The French multicenter CLOTVID retrospective study.
Not available
S-EPMC8239942 | biostudies-literature
UnknownDetection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives.
Not available
S-EPMC7724284 | biostudies-literature
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