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MetabolomicsAn NMR metabolomics analysis pipeline for human neutrophil samples with limited source material
Untargeted 1H NMR metabolomics is a robust and reproducible approach to study metabolism in biological samples, providing unprecedented insight into altered cellular processes associated with human diseases. Metabolomics is increasingly used alongside other -omics techniques, such as proteomics and ...
2025-11-06 | MTBLS6220 | MetaboLights
TranscriptomicsTranscription profiling of mouse LE-AP-2a mutants vs. wild-type P0 littermate lenses to investigate cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
This is a comparative microarray analysis of LE-AP-2a mutants vs. wild-type P0 littermate lenses. This analysis revealed differential gene expression of 415 mRNAs, including reduced expression of genes important for maintaining lens epithelial cell phenotype, such as E-cadherin. Experiment Overall D...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14536 | biostudies-arrayexpress
GenomicsChlamydia pecorum strain:Nar/S42/LE
Chlamydia pecorum Nar/S42/LE Genome sequencing
PRJNA269197 | ENA
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS382 | MetaboLights
MetabolomicsEFFECT OF DIFFERENT POOLED QC SAMPLES ON DATA QUALITY DURING AN INTER-BATCH EXPERIMENT IN UNTARGETED UHPLC-HRMS ANALYSIS ON TWO DIFFERENT MS PLATFORMS
Quality control (QC) samples are commonly used in metabolomics approaches for three main reasons: (i) the initial conditioning of the column; (ii) the correction of analytical drift especially between batches; and (iii) the evaluation of measurement precision. In practice there are several ways to p...
2026-02-04 | MTBLS10568 | MetaboLights
MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
MetabolomicsIdentification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial.

BACKGOUND: Ultra-processed food (UPF) accounts for a majority of calories consumed in the United States, but the impact on human health remains unclear. We aimed to identify poly-metabolite scores in blood and urine that are predictive of UPF intake.

METHODS AND FIN...

2025-07-12 | MTBLS12705 | MetaboLights
TranscriptomicsGene expression and H3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants
This SuperSeries is composed of the following subset Series: GSE24464: Expression analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants GSE24474: H3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual di...
ORGANISM(S): Arabidopsis thaliana 
2011-04-20 | E-GEOD-24507 | biostudies-arrayexpress
ProteomicsIdentification of the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity in the rat liver.
To identify the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity we purified subcellular organelles including cytosol, late endosomes (LE/MVBs) and lysosomes (CMA+) from the rat liver and performed co-Ip experiment with antibodies directed against the major cellular...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-26 | PXD046797 | Pride
Cma vs microautophagy  hsc-70-co-ip-ms/ms in late endosomes Rat liver Lysosomes and cytosol 
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