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MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
TranscriptomicsA role for Prenylated rab acceptor 1 in vertebrate photoreceptor development
The rd1 mouse retina is a well-studied model of retinal degeneration where rod photoreceptors undergo cell death beginning at postnatal day P10 until P21. This period coincides with photoreceptor terminal differentiation in a normal retina. We have used the rd1 retina as a model to investigate early...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-41821 | biostudies-arrayexpress
TranscriptomicsThe G Protein-coupled Receptor P2Y14 Influences Insulin Release and Smooth Muscle Function in Mice
UDP-sugars were identified as extracellular signaling molecules, assigning a new function to these compounds in addition to their well defined role in intracellular substrate metabolism and storage. Previously regarded as an orphan receptor, the G protein-coupled receptor (GPCR) P2Y14 (GPR105) was f...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59285 | biostudies-arrayexpress
TranscriptomicsKnockdown of Hnrnpa0, a del(5q) Gene, Alters Myeloid Cell Fate in Murine Cells
To understand the effect of loss of Hnrnpa0, an RNA-binding protein shown to regulate transcript stability via binding to the AU-rich elements (AREs) of mRNAs, on myelopoiesis, we used RNAi interference to model Hnrnpa0 loss in an experimental murine cell system, and then used global expression prof...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39934 | biostudies-arrayexpress
UnknownA mHealth intervention to preserve and promote ideal cardiovascular health in college students: Design and protocol of a cluster randomized controlled trial.
Not available
S-EPMC7686283 | biostudies-literature
TranscriptomicsInfection of duck with avian influenza H5N1 and H5N2 viruses
Transcriptional profiling was carried out on lung and ileum samples at 1dpi and 3dpi from ducks infected with either low pathogenic (H5N2) or highly pathogenic (H5N1) avian influenza. Infected birds were compared to control birds at each time point.
ORGANISM(S): Anas platyrhynchos 
2015-01-19 | E-MTAB-2909 | biostudies-arrayexpress
TranscriptomicsInfection of chicken with avian influenza H5N1 and H5N2 viruses
Transcriptional profiling was carried out on lung and ileum samples at 1dpi and 3dpi from chickens infected with either low pathogenic (H5N2) or highly pathogenic (H5N1) avian influenza. Infected birds were compared to control birds at each time point.
ORGANISM(S): Gallus gallus 
2015-01-19 | E-MTAB-2908 | biostudies-arrayexpress
TranscriptomicsRRBS of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele
Pancreatic adenocarcinoma (PDAC) is a lethal disease and it is the most common type of pancreatic cancer. Majority of the pancreatic cancers harbor alterations in the Kras gene. Currently there are no approved drugs that target Kras directly and it's downstream effect on the epigenome remains unkno...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10900 | biostudies-arrayexpress
TranscriptomicsRNA-seq of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele
Pancreatic adenocarcinoma (PDAC) is a lethal disease and it is the most common type of pancreatic cancer. Majority of the pancreatic cancers harbor alterations in the Kras gene. Currently there are no approved drugs that target Kras directly and it's downstream effect on the epigenome remains unkno...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10896 | biostudies-arrayexpress
TranscriptomicsKnockdown of Hnrnpa0, a del(5q) Gene, Alters Myeloid Cell Fate in Murine Cells through Regulation of AU-rich Transcripts
The post-transcriptional control of mRNA stability plays a critical role in numerous biological functions, including the immune response, cell cycle regulation and DNA damage response. HNRNPA0, which encodes an RNA-binding protein shown to regulate transcript stability via binding to the AU-rich el...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-39991 | biostudies-arrayexpress
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