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TranscriptomicsVL30 retro-transposons are TRIM24-repressed enhancers that generate non-coding RNA to regulate gene expression in mouse hepatocytes.
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ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39853 | biostudies-arrayexpress
GenomicsVL30 retro-transposons are TRIM24-repressed enhancers that generate non-coding RNA to regulate gene expression in mouse hepatocytes. [ChIP-Seq]
TRIM24 and TRIM33 interact to form a corepressor complex that suppresses murine hepatocellular carcinoma (HCC). TRIM24 and TRIM33 cooperatively repress retinoic acid receptor dependent activity of VL30 retro-transposons in hepatocytes in vivo. In TRIM24 knockout hepatocytes, VL30 long terminal repea...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39852 | biostudies-arrayexpress
TranscriptomicsChromatin dynamics and genome-wide profiling of repetitive elements during early mammalian embryogenesis.
We have used repetitive elements, including retrotransposons, as model loci to address how and when heterochromatin forms during development. High throughput RNA-sequencing using a Nano-CAGE protocol throughout early embryogenesis revealed that the expression of repetitive elements is abundant in...
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-39849 | biostudies-arrayexpress
GenomicsEssential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-speci...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-64137 | biostudies-arrayexpress
TranscriptomicsIGR_MACROPHAGE_MOUSE_MUTATION_CEA_PHR
Macrophage activation during the innate immune response is tightly regulated to prevent tissue damage while activating the defense to cellular attack. Using a mouse model where Trim33 is specifically deleted in mature myeloid cells, we show that TRIM33 is essential for two aspects of the inflammator...
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-1441 | biostudies-arrayexpress
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