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TranscriptomicsRole of miR-125b in B-cell acute lymphoblastic leukemia (B-ALL)
B-cell acute lymphoblastic leukemia (B-ALL) is often associated with chromosomal translocations leading to the deregulation of proto-oncogenes. MicroRNAs can also be affected by chromosomal alterations and thus contribute to carcinogenesis. The microRNA miR-125b-1 is over-expressed in B-ALL cases wi...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-30647 | biostudies-arrayexpress
TranscriptomicsSmall RNA next generation sequencing of mice skin biopsies from acetone-treated healthy skins and DMBA/PMA-treated hyperplastic skins, papillomas and cutaneous Squamous Cell Carcinomas
FVB/N mice were subjected to 7,12-Dimethylbenz[a]anthracene (DMBA) two-hit multistage skin carcinogenesis protocol. Mice were topically treated with 200 nmol of DMBA in 0.2 mL acetone then twice weekly for six weeks with 5 nmol PMA (Phorbol 12-myristate 13-acetate). A second hit of DMBA was performe...
ORGANISM(S): Mus musculus 
2014-02-03 | E-GEOD-52299 | biostudies-arrayexpress
TranscriptomicsEffect of mmu-miR-193b-3p and miR-365a-3p ectopic expression on the transcriptome of mouse cutaneous Squamous Cell Carcinoma cells
The mouse mSCC-20 cell line was transfected with 5nM of mmu-pre-miR-193b-3p, pre-miR-365a-3p or pre-miR-NC1. Total RNAs were extracted 30 h after transfection and hybridized on microarrays. One color experiment with 3 experimental conditions : miR-NC1- (n=4), miR-193b-3p- (n=2) and miR-365-3p- (n=2)...
ORGANISM(S): Mus musculus 
2014-02-03 | E-GEOD-52381 | biostudies-arrayexpress
TranscriptomicsRole of miR-210 in late stages of lung cancer: mitochondrial alterations associated with a modulation of HIF1 activity
Recent studies have identified miR-210 among a set of hypoxia-regulated miRNAs, and shown the central regulatory role played by HIF to control transcription of this miRNA. Contradictory data exist concerning the regulation and roles of miR-210 during cancer progression. miR-210 appears at the same t...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-18805 | biostudies-arrayexpress
TranscriptomicsDistinct epithelial gene expression phenotypes in childhood respiratory allergy
This SuperSeries is composed of the following subset Series: GSE19182: Gene expression profiling of differentiated HNECs stimulated by IL4, IL13, IFNalpha, IFNbeta, IFNgamma and controls GSE19187: Nasal epithelium gene expression profiling in child respiratory allergic disease Refer to individual Se...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-19190 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ on resting (R) and stimulated (S) B cells from several IgH 3'RR mutant models
We evaluated by RNA-seq obveral transcripts in B cells (resting and activated for 2 days with LPS) sorted from several KO mice models devoid of portion or all the IgH 3' Regulatory Region One RNA-seq point was realized per condition (resting or stimulated) and per genotype. Each point corresponds to...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76217 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of Bmi1 silenced-K562 CML cell line
The Bmi1 Polycomb protein is involved in the epigenetic repressive control of self renewal and survival of cancer initiating cells. In Chronic Myeloid Leukemia (CML), bmi1 expression increases gradually as the disease progresses from a chronic latent phase to a deadly blast crisis. We developped an ...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-54262 | biostudies-arrayexpress
TranscriptomicsTetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways, but so far, it is unclear how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-lik...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-61957 | biostudies-arrayexpress
UnknownmiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-43622 | biostudies-other
TranscriptomicsmiRNAs high throughput sequencing profiling of basals cells and columnar cells
The airway mucociliary epithelium is consituted of three main cell types : columnar ciliated plus secretory cells and basal cells. Columnar cells are represented by a great majority of ciliated cells. We used Cell sorting by FACSaria to separate basal cells from ciliated and secreting columnar cell...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22145 | biostudies-arrayexpress
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