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TranscriptomicsATAC-seq analysis of the day-night rhythm in chromatin accessibility in PCM1+ left ventricular cardiomyocyte nuclei
This study investigated differential chromatin accessibility at zeitgeber time (ZT) 0 denoting the start of the light/inactive period in mice compared to ZT12 (the start of the dark/active) period to obtain insights into diurnal changes in transcription factor binding and gene regulatory pathways in...
ORGANISM(S): Mus musculus 
2024-02-29 | E-MTAB-13696 | biostudies-arrayexpress
MetabolomicsMetabolomic Analysis of Incurrent and Excurrent Water From Sponges

Sponges are sessile filter-feeders that can process vast amounts of water and are known to influence the chemistry of the surrounding seawater. There has been limited work however to understand the extent to which sponges alter dissolved organic matter (DOM), yet in areas where sponges are abunda...

2025-10-21 | MTBLS13194 | MetaboLights
ProteomicsThe microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism
Efforts to identify anti-cancer therapeutics are attempted with in vitro models that do not match the microenvironmental characteristics of human tissues. Using biocompatible hydrogels that mimic healthy or cancerous tissues and conventional or physiologically relevant culture medium, we systematica...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD044309 | Pride
Ecm Metabolism Glycosylation Lc-ms/ms Mechanopharmacology 
TranscriptomicsThe fine-scale and complex architecture of human copy number variation
Despite considerable excitement over the potential functional significance of copy number variants (CNVs), we still lack knowledge of the fine-scale architecture of the large majority of CNV regions in the human genome. In this study, we used a high-resolution array-based comparative genomic hybridi...
ORGANISM(S): Homo sapiens 
2008-01-23 | E-GEOD-9831 | biostudies-arrayexpress
TranscriptomicsNFAT-dependent IL-2 and IL-23 produced by DC are key regulators of pathogenic (TH17-mediated lung inflammation)
Calcineurin/NFAT/IL-2 signaling pathway is activated in dendritic cells (DC) upon encounter of β glucan, the main component of the fungal cell wall, raising the question about the role of NFAT-regulated genes in DC biology in vivo. To directly assess the function of IL-2 secreted by DC, we analyzed...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-58590 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of melanoma brain metastases and matched extracranial metastases
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50493 | biostudies-arrayexpress
TranscriptomicsSomatic copy number variation profiling in matched brain and extracranial metastases of melanoma
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50495 | biostudies-arrayexpress
UnknownIntrinsic Disorder in BAP1 and Its Association with Uveal Melanoma.
Not available
S-EPMC9601668 | biostudies-literature
UnknownBioinformatics-Based Comparative Analysis of the Human Retina Proteome.
Not available
S-EPMC12278036 | biostudies-literature
ProteomicsHigh-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Glioblastoma, the most aggressive primary brain cancer, has dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities of glioblastoma. To this end, we here syste...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090357 | MassIVE
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