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The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec;40(22):11339-51. We examined DNA methylation and RNA expression status during early B-cell development by sorting mu...
ORGANISM(S): Homo sapiens 
To determine the roles of membrane associated IFITM3 in BCR-signalling in B-cell malignancies we expressed N-terminal BirA-IFITM3-Y20E fusion or BirA-EV control in patient derived B-ALL cells (PDX2) and Jeko1 Mantle cell lymphoma (MCL) cells. Additionally to examine the role of PIP3 binding residues...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020697 | Pride
abundance based on iBAQ, Interaction consistency score: 10.0, Coverage: 8
ORGANISM(S): 10090 
2019-00-00 | 3223737855 | PAXDB
abundance based on iBAQ, Interaction consistency score: 11.5, Coverage: 8
ORGANISM(S): 10090 
2019-00-00 | 1257877986 | PAXDB
A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec;40(22):11339-51. We examined DNA methylation and RNA expression status during early B-cell development by sorting mu...
ORGANISM(S): Homo sapiens 
Treatment induced senescence (TIS) is a terminal cell cycle arrest program, increasingly recognized as a tumor suppressor mechanism complementing apoptosis in response to standard chemotherapy regimens. In particular cells with blocked apoptotic pathways rely on senescence as the only remaining fail...
ORGANISM(S): Mus musculus 
We examined the major patterns of changes in gene expression in mouse splenic B cells in response to stimulation with 33 single ligands for 0.5, 1, 2, and 4 h. We found that ligands known to directly induce or costimulate proliferation, namely, anti-IgM (anti-Ig), anti-CD40 (CD40L), LPS, and, to a l...
ORGANISM(S): Mus musculus 
Memory B cells play a fundamental role in host defenses against viruses. This dataset aimed at understanding the recruitment and remodeling of the memory B cell repertoire in the context of BA.1-breakthrough infection in BNT162b2 mRNA vaccinated individuals. All four donors enrolled in the study had...
ORGANISM(S): Homo sapiens 
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