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ProteomicsExtensive Three-Dimensional Intratumor Proteomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens
Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOC) and analyzed by mass spectrometry. Unsupervised analyses of protein abundance data rev...
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD026570 | Pride
Laser microdissection Proteomics Heterogeneity High grade serous ovarian cancer Tumor microenvironment 
UnknownBayesian adaptive randomized trial design for patients with recurrent glioblastoma.
Not available
S-EPMC3434985 | biostudies-literature
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
MetabolomicsSpatially-guided metabolomics profiling of heterogeneous human tumor tissues

Bulk high-resolution mass spectrometry can provide sensitive and global snapshots of metabolites involved in cancer metabolism. However, intra-tumor heterogeneity (IntraTH) convolutes the cellular origins and tumor pathologies associated with the detected metabolites, thus making the elucidation ...

2026-04-15 | MTBLS13432 | MetaboLights
ProteomicsC. elegans as a model for inter-individual variation in metabolism
Fox BW, Ponomarova O, Lee YU, Zhang G, Giese EG, Walker M, Roberto NM, Na H, Reis-Rodrigues P, Curtis BJ, Kolodziej AR, Crombie TA, Zdraljevic S, Yilmaz LS, Andersen EC, Schroeder FC, Walhout AJM (2022) C. elegans as a model for inter-individual variation in metabolism
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2021-07-13 | MSV000087810 | MassIVE
TranscriptomicsRNA-seq (Illumina and PacBio) of hESC
We used PacBio data to identify more reliable transcripts from hESC, based on which we can estimate gene/transcript abundance better from Illumina data. PacBio long reads and Illumina short reads were generated from the same hESC cell line H1. PacBio reads were error-corrected by Illumina reads to i...
ORGANISM(S): Homo sapiens 
2013-10-30 | E-GEOD-51861 | biostudies-arrayexpress
TranscriptomicsThe microRNA expression profile of C2C12 cell upon 72 hours of BMP2 treatment
To identify osteoblast specific miRNAs that can contribute to osteoblastogenesis by post-transcriptionally regulates their targets, BMP2 are treated to C2C12 for 72 hours and performed miRNA microarray. C2C12 cells were treated with vehicles or BMP2 (300 ng/mL) supplemented alpha-MEM media for 72 da...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-37036 | biostudies-arrayexpress
TranscriptomicsThe global gene expression profile of gain of function miR34c in osteoblast
To examine the unbiased global gene expression of gain of miR34c in committed osteoblast in mouse we have performed expression microarray. This approach will allow us to define the novel targets that are negatively regulated by over-expression of miR34c in osteoblast. Total RNA was isolated from pri...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-36780 | biostudies-arrayexpress
GenomicsNext Generation Mendelian Genetics: Atypical Werner Syndrome

Werner syndrome (WS) is an adult-onset progeroid syndrome characterized by accelerated aging. The International Registry of Werner Syndrome in the Department of Pathology, University of Washington, collects WS cases from all over the world. Classical WS is caused by WRN mutations. Those who do no...

phs000434.v1.p1 | EGA
GenomicsDynamic loss of H2B ubiquitylation without corresponding changes in H3K4 tri-methylation during myogenic differentiation
Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation. H2Bub has been implicated in histone cross-talk and is generally regarded to be a prerequisite for H3K4 and H3K79 tri-methylation in both yeast and mammalian cells. We performed a genome-wide analysis o...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-34960 | biostudies-arrayexpress
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