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TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
TranscriptomicsThe anti-proliferative effects of progestins in T47D breast cancer cells are tempered by progestin-induction of the ETS transcription factor Elf5.
Prolactin and progesterone act together to regulate mammary alveolar development, and both hormones have been implicated in breast cancer initiation and progression. Here we show that Elf5, a prolactin-induced ETS transcription factor that specifies the mammary secretory cell lineage, is also induce...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-22363 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation genome wide location analysis of yeast transcriptional regulators under multiple growth conditions
Genomic binding of 203 transcriptional regulatory proteins under various conditions. Hybridizations of fluorescently-labelled immunoprecipitated vs. whole-cell extract samples on S. cerevisiae intergenic arrays.
ORGANISM(S): Saccharomyces cerevisiae 
2004-09-02 | E-WMIT-10 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE20529: Promoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip GSE20530: Promoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-20485 | biostudies-arrayexpress
UnknownCytokine Storms in COVID-19, Hemophagocytic Lymphohistiocytosis, and CAR-T Therapy.
Not available
S-EPMC11976493 | biostudies-literature
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of transcription factor binding in yeast cells perturbed with methyl-methanesulfonate
Genome-wide promoter-binding analysis of transcription factors in S.cerevisiae cells perturbed with 0.03% methyl-methanesulfonate for 60 minutes
ORGANISM(S): Saccharomyces cerevisiae 
2006-05-19 | E-TABM-92 | biostudies-arrayexpress
TranscriptomicsDeletion of the Mammalian INDY Homologue in Mice Mimics Aspects of Dietary Restriction and Protects Against Diet and Age-Induced Adiposity and Insulin Resistance
Reduction in expression of the INDY gene in Drosophila melanogaster and Caenorhabditis elegans prolongs life span, and in D. melanogaster augments mitochondrial biogenesis in a manner akin to caloric restriction. However, the cellular mechanism by which INDY does this is unknown. In order to examine...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-29984 | biostudies-arrayexpress
TranscriptomicsThymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation
A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA m...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-43435 | biostudies-arrayexpress
GenomicsDynamic loss of H2B ubiquitylation without corresponding changes in H3K4 tri-methylation during myogenic differentiation
Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation. H2Bub has been implicated in histone cross-talk and is generally regarded to be a prerequisite for H3K4 and H3K79 tri-methylation in both yeast and mammalian cells. We performed a genome-wide analysis o...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-34960 | biostudies-arrayexpress
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