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TranscriptomicsFunctional Connection with Cardiac Tissues Confers Maturation Phenotypes in hPSC-Derived PHOX2B::GFP Expressing Sympathetic Neurons
Neurons derived from human pluripotent stem cells (hPSCs) are a remarkable tool for modeling human neural development and diseases. However, it remains largely unknown whether the hPSC-derived neurons can be functionally coupled with their target tissues in vitro, which is essential for understandin...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-80689 | biostudies-arrayexpress
TranscriptomicsMolecular and functional characterization of FD-iPSC derived neural crest precursor cells
Global gene expression analysis of FD-iPSC and deribved neural crest cells Here we report the derivation of patient specific Familial Dysautonomia-iPSCs and their directed differentiation into multiple cell types capable of modeling the tissue specific splicing defect in vitro. Undifferentiated hES...
ORGANISM(S): Homo sapiens 
2009-08-31 | E-GEOD-17043 | biostudies-arrayexpress
TranscriptomicsHuman iPSC-based model for Duchenne muscular dystrophy
We developed a novel somite-based step-wise strategy for the efficient derivation of functional human myocytes, suggesting that past failures were due to incomplete specification. Treatment with two small molecules inhibiting glycogen synthase kinase 3β (GSK-3β) and the Notch signaling pathway in ...
ORGANISM(S): Homo sapiens 
2016-06-16 | E-GEOD-70955 | biostudies-arrayexpress
TranscriptomicsComparing isogenic pairs of hESC and hiPSC lines reveals genetic background and reprogramming method as primary sources of transcriptional variation
The equivalency of human induced pluripotent stem cells (hiPSCs) with human embryonic stem cells (hESCs) remains controversial. Here, we devised a strategy to assess the contribution of clonal growth, reprogramming method and genetic background to transcriptional patterns in hESCs and hiPSCs. Surpri...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73211 | biostudies-arrayexpress
TranscriptomicsComparison of human embroynic stem cell derived vascular cells to mature human vascular and hematopoietic cells
The pathways involved in hierarchical differentiation of human embryonic stem cells (hESC) into abundant and durable endothelial cells (EC) are unknown. We employed an EC-specific VE-cadherin promoter driving GFP (hVPr-GFP) to screen for factors that augmented yields of vascular-committed ECs from h...
ORGANISM(S): Homo sapiens 
2010-01-05 | E-GEOD-19735 | biostudies-arrayexpress
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