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UnknownIL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.
Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old ...
S-EPMC5240661 | biostudies-literature
UnknownIdentification and characterization of the flavin:NADH reductase (PrnF) involved in a novel two-component arylamine oxygenase.
Two-component oxygenases catalyze a wide variety of important oxidation reactions. Recently we characterized a novel arylamine N-oxygenase (PrnD), a new member of the two-component oxygenase family (J. Lee et al., J. Biol. Chem. 280:36719-36728, 2005). Although arylamine N-oxygenases are widespread ...
S-EPMC2168932 | biostudies-literature
UnknownSingle-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis.
Periodontitis affects billions of people worldwide. To address relationships of periodontal niche cell types and microbes in periodontitis, we generated an integrated single-cell RNA sequencing (scRNAseq) atlas of human periodontium (34-sample, 105918-cell), including sulcular and junctional keratin...
S-EPMC11178863 | biostudies-literature
UnknownCondensing water vapor to droplets generates hydrogen peroxide.
It was previously shown [J. K. Lee et al., Proc. Natl. Acad. Sci. U.S.A, 116, 19294-19298 (2019)] that hydrogen peroxide (H2O2) is spontaneously produced in micrometer-sized water droplets (microdroplets), which are generated by atomizing bulk water using nebuliza...
S-EPMC7733789 | biostudies-literature
UnknownAn association between diet quality index for Koreans (DQI-K) and total mortality in Health Examinees Gem (HEXA-G) study.
BACKGROUND/OBJECTIVES:Diet quality scores or indices, based on dietary guidelines, are used to summarize dietary intake into a single numeric variable. The aim of this study was to examine the association between the modified diet quality index for Koreans (DQI-K) and mortality among Health Examinee...
S-EPMC5974072 | biostudies-literature
UnknownJ-shaped association between LDL cholesterol and cardiovascular events: A longitudinal primary prevention cohort of over 2.4 million people nationwide.

Introduction

Low-density lipoprotein (LDL) cholesterol-lowering treatment is beneficial for the secondary or primary prevention of high-risk atherosclerotic cardiovascular disease (ASCVD). However, the prognostic implications of low LDL cholesterol levels in patients without previous ASCVD a...
S-EPMC10982857 | biostudies-literature
UnknownSocioeconomic inequalities in the prevalence of biomarkers of cardio-metabolic disease in South Korea: Comparison of the Health Examinees Study to a nationally representative survey.

Background/objectives

This study aimed to examine socioeconomic inequalities in the prevalence of biomarkers of cardiovascular disease and diabetes in the newly developed large-scale genomic cohort study of Korean adults, the Health Examinees-Gem (HEXA-G), with a comparison of the nationally...
S-EPMC5906014 | biostudies-literature
UnknownDevelopment of the Korean Developmental Screening Test for Infants and Children (K-DST).

Background

Most developmental screening tools in Korea are adopted from foreign tests. To ensure efficient screening of infants and children in Korea, a nationwide screening tool with high reliability and validity is needed.

Purpose

This study aimed to independently develop, standardi...
S-EPMC7642140 | biostudies-literature
UnknownPurification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe.
We have purified and characterized a novel 60-kDa protein that binds to centromeric K-type repeat DNA from Schizosaccharomyces pombe. This protein was initially purified by its ability to bind to the autonomously replicating sequence 3002 DNA. Cloning of the gene encoding this protein revealed that ...
S-EPMC22944 | biostudies-literature
UnknownA novel ENU-induced mutation, peewee, causes dwarfism in the mouse.
We identified a novel fertile autosomal recessive mutation called peewee that results in dwarfing, in a region-specific ENU-induced mutagenesis. These mice at litter size were smaller those of other strains. Histological analysis revealed that the major organs appear normal, but abnormalities in cel...
S-EPMC2921851 | biostudies-literature
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