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ProteomicsQuantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis
Although biomarker candidates associated with psoriasis have been suggested, those for predicting the risk of cardiovascular disease (CVD) early in patients with psoriasis are lacking. We aimed to identify candidate biomarkers that can predict the occurrence of CVD in psoriasis patients. We pursued ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD039645 | Pride
Psoriasis Cardiovascular risk Lc-ms/ms Tandem mass tags 
ProteomicsDiesel particulate matter-induced proteomic changes in three-dimensional spheroids derived from human primary cells of various tissue origins
This study investigated the effects of diesel particulate matter (DPM) on multiple human organs using 3D spheroids derived from eight human primary cell types. To assess the impact of DPM, we exposed these spheroids to varying concentrations of standardized DPM (SRM 2975) and measured their viabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD056979 | Pride
Three-dimensional (3d) spheroids Mass spectrometry (ms) Diesel particulate matter (dpm) Viability assessment Tandem mass tag (tmt) 
ProteomicsProteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE-/- mice exposed to diesel exhaust particles
Air pollution is an environmental risk factor linked to multiple human diseases including cardiovascular diseases (CVDs). While particulate matter (PM) emitted by diesel exhaust damages multiple organ systems, heart disease is one of the most severe pathologies affected by PM. However, the in vivo e...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-09 | PXD045029 | Pride
Platelet Diesel exhaust particles Tgfβ Heart fibrosis Proteomic analysis 
UnknownOdontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.
Not available
S-EPMC4505539 | biostudies-literature
UnknownNaturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naive Korean patients infected with genotype C2.
Not available
S-EPMC5483496 | biostudies-literature
ProteomicsComprehensive analysis of symmetric arginine dimethylation in colorectal cancer tissues from patients using immuniaffinity enrichment followed by LC-MS/MS analysis
Post-translational arginine methylation is responsible for regulation of a variety of biological processes. The protein arginine methyltransferase 5 (PRMT5) is the major enzyme responsible for generating monomethyl- and symmetric dimethyl arginine (MMA and SDMA, respectively) in proteins. PRMT5 is e...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD015653 | Pride
Prmt5 Immunoaffinity enrichment Colorectal cancer Mass spectrometry Symmetric arginine methylation 
TranscriptomicsThe responses of astrocytes stimulated by extracellular a-synuclein
Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction b...
ORGANISM(S): Rattus norvegicus 
2010-01-11 | E-GEOD-11574 | biostudies-arrayexpress
TranscriptomicsPTIP-regulated genes in MEF
PPARg and C/EBPa cooperate to control preadipocyte differentiation (adipogenesis). However, the factors that regulate PPARg and C/EBPa expression during adipogenesis remain largely unclear. Here we show PTIP, a protein that associates with histone H3K4 methyltransferases, regulates PPARg and C/EBPa ...
ORGANISM(S): Mus musculus 
2009-05-29 | E-GEOD-16263 | biostudies-arrayexpress
UnknownRel-dependent decrease in the expression of ribosomal protein genes by inhibition of the respiratory electron transport chain in Mycobacterium smegmatis.
Not available
S-EPMC11345224 | biostudies-literature
TranscriptomicsTranscription profiling by array of human HepG2/C3A cells cultured in complete or leucine-devoid medium
HepG2/C3A cells cultured for 42 h in complete or leucine-devoid medium Experiment Overall Design: Total of 6 Samples (Leu vs noLeu)
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13142 | biostudies-arrayexpress
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