Sort   by:  
 Page size 
ProteomicsSynphilin-1 upregulates RBL2 expression and causes a G0/G1 phase cell cycle arrest in the neurons
Synphilin-1, a major component of Lewy bodies in the brain of Parkinsons disease (PD) patients, is a cytoplasmic protein that interacts with alpha-synuclein and is suggested to have cytoprotective effects in the neuronal cells. alpha-Synuclein overexpression induced re-entry of the neuronal cells in...
ORGANISM(S): Mus <mouse, Genus> (ncbitaxon:10088) 
2022-07-20 | MSV000089926 | MassIVE
UnknownImplementation of a Nurse-Delivered Cognitive Behavioral Therapy for Adherence and Depression of People Living with HIV in Korea.

Background

Cognitive behavioral therapy for adherence and depression (CBT-AD) performed by clinical psychologists is an effective treatment for improving the depression in people living with HIV (PLWH). However, because access to clinical psychologists is limited in most clinics, CBT-AD is r...
S-EPMC9840965 | biostudies-literature
UnknownAltered Cerebral Curvature in Preterm Infants Is Associated with the Common Genetic Variation Related to Autism Spectrum Disorder and Lipid Metabolism.
Preterm births are often associated with neurodevelopmental impairment. In the critical developmental period of the fetal brain, preterm birth disrupts cortical maturation. Notably, preterm birth leads to alterations in the fronto-striatal and temporal lobes and the limbic region. Recent advances in...
S-EPMC9181724 | biostudies-literature
UnknownExternal Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old.
BACKGROUND:Previously, a linked pharmacokinetic-pharmacodynamic model (the Kim model) of propofol with concurrent infusion of remifentanil was developed for children aged 2-12 years. There are few options for pharmacokinetic-pharmacodynamic model of propofol for children under two years old. We perf...
S-EPMC7086090 | biostudies-literature
UnknownThe Kynurenine Pathway and Mediating Role of Stress in Addictive Disorders: A Focus on Alcohol Use Disorder and Internet Gaming Disorder.
Stress plays an important role in the pathophysiology of addictive disorders. The kynurenine (KYN) pathway involved in neuroimmune and cognitive functions is activated under stress. However, the neuroimmunological-neurocognitive mechanisms in the role of stress in addictive disorders are unclear sti...
S-EPMC9037037 | biostudies-literature
UnknownHuman podoplanin-positive monocytes and platelets enhance lymphangiogenesis through the activation of the podoplanin/CLEC-2 axis.
Emerging studies suggested that murine podoplanin-positive monocytes (PPMs) are involved in lymphangiogenesis. The goal of this study was to demonstrate the therapeutic lymphangiogenesis of human PPMs by the interaction with platelets. Aggregation culture of human peripheral blood mononuclear cells ...
S-EPMC4435587 | biostudies-literature
UnknownKAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.

Background

Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance.

Methods

Herein, we found Kai1 knockout m...
S-EPMC8444549 | biostudies-literature
UnknownStructure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A<sub>2A</sub>/A<sub>3</sub> Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.
Based on hA2AAR structures, a hydrophobic C8-heteroaromatic ring in 5'-truncated adenosine analogues occupies the subpocket tightly, converting hA2AAR agonists into antagonists while maintaining affinity toward hA3AR. The final compounds of 2,8-disubstituted-N...
S-EPMC10896643 | biostudies-literature
UnknownCoronary Artery Calcification Score and the Progression of Chronic Kidney Disease.

Background

An elevated coronary artery calcification score (CACS) is associated with increased cardiovascular disease risk in patients with CKD. However, the relationship between CACS and CKD progression has not been elucidated.

Methods

We studied 1936 participants with CKD (stages G1...
S-EPMC9342644 | biostudies-literature
UnknownMultiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We r...
S-EPMC4284402 | biostudies-literature
Sort   by:  
 Page size