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TranscriptomicsPopulation transcriptional profiling of KO or WT cells,, differentiated in vitro for 48-96h towards Th17 cells
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75104 | biostudies-arrayexpress
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Memory in Alzheimer's Disease Mice
Here, we present findings from a drug discovery program aimed at developing small molecules that enhance brain sCLU levels and assessed their impact on AD pathology and cognition. A high-throughput screening campaign identified two classes of epigenetic modulators to increase sCLU levels, and medici...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060171 | Pride
Alzheimers disease Epigenetic modulator Memory improvement Secreted clustering enhancer 
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
UnknownIbrutinib for First-Line Treatment of Chronic Graft-Versus-Host Disease: Results From the Randomized Phase III iNTEGRATE Study.
Not available
S-EPMC10082299 | biostudies-literature
UnknownSouthwest Oncology Group S0008: a phase III trial of high-dose interferon Alfa-2b versus cisplatin, vinblastine, and dacarbazine, plus interleukin-2 and interferon in patients with high-risk melanoma--an intergroup study of cancer and leukemia Group B, Children's Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group.
Not available
S-EPMC4226807 | biostudies-literature
ProteomicsUnbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in SCLC
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, inhibits SCLC expansion in culture and in vivo. Conversely, GNAS (G-protein ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-06-17 | PXD018209 | Pride
Inhibitor beads Analog specific Kinase proteomics Small cell lung cancer 
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
TranscriptomicsGenotype profiling of primitive neuroectodermal tumours (250K_Nsp_SNP and 250K_Sty_SNP)
Primitive neuro-ectodermal tumours (PNET) of the supratentorial region are rare, highly malignant embryonal brain tumours affecting young children. Although supratentorial PNET (sPNET) are histologically similar to infratentorial PNET/medulloblastoma, sPNET have more aggressive clinical phenotypes, ...
ORGANISM(S): Homo sapiens 
2009-12-21 | E-GEOD-14087 | biostudies-arrayexpress
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
UnknownLiposomal Irinotecan + 5-FU/LV in Metastatic Pancreatic Cancer: Subgroup Analyses of Patient, Tumor, and Previous Treatment Characteristics in the Pivotal NAPOLI-1 Trial.
Not available
S-EPMC6946097 | biostudies-literature
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