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UnknownWeekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma.

Aim

To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC).

Methods

A multi-center, open-label, prospective phase II study was designed. Thirty-three esophageal SCC patients with document...
S-EPMC4394089 | biostudies-literature
UnknownSRSF3 Is a Critical Requirement for Inclusion of Exon 3 of BIS Pre-mRNA.
BCL-2 interacting cell death suppressor (BIS), also known as BAG3, is a multifunctional protein. Aberrant expression and mutation of BIS have been implicated in cancers and myopathy. However, there have only been a few studies on the splicing of BIS pre-mRNA. In the present study, through RT-PCR and...
S-EPMC7589869 | biostudies-literature
UnknownHomotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics.
The ER regulates the spatiotemporal organization of endolysosomal systems by membrane contact. In addition to tethering via heterotypic interactions on both organelles, we present a novel ER-endosome tethering mechanism mediated by homotypic interactions. The single-pass transmembrane protein SCOTIN...
S-EPMC10398665 | biostudies-literature
UnknownFocal Dorsal Enhancement of the Tympanic Bulla: An Early Indicator in Feline Otitis Media.
Evaluating the morphological changes of the tympanic bulla and the contrast enhancement (CE) patterns are key factors in diagnosing otitis media and predicting its underlying etiology. However, limited research exists on the CE patterns of the tympanic bulla in cats with bulla effusion. This retrosp...
S-EPMC11911501 | biostudies-literature
UnknownClinical Implications of Circulating Tumor DNA in Multiple Myeloma and Its Precursor Diseases.

Background

Genetic alterations play a pivotal role in multiple myeloma (MM) development and therapeutic resistance. Traditionally, the genetic profiling of MM requires invasive bone marrow (BM) procedures; however, these procedures are associated with patient discomfort and cannot fully capt...
S-EPMC11996693 | biostudies-literature
UnknownExamining neoadjuvant treatment candidates in resectable pancreatic cancer based on tumor-vessel interactions and CA 19-9 levels: a retrospective cohort study.

Introduction

The applicability of neoadjuvant treatment (NAT) for resectable pancreatic ductal adenocarcinoma (PDAC) has arisen, however, high-level evidence is lacking. This study aimed to explore patient subgroups with high-risk resectable PDAC for selecting candidates who may benefit from...
S-EPMC11093487 | biostudies-literature
UnknownUnderstanding metal-enhanced fluorescence and structural properties in Au@Ag core-shell nanocubes.
Au@Ag core-shell structures have received particular interest due to their localized surface plasmon resonance properties and great potential as oxygen reduction reaction catalysts and building blocks for self-assembly. In this study, Au@Ag core-shell nanocubes (Au@AgNCs) were fabricated in a facile...
S-EPMC9071844 | biostudies-literature
UnknownOsmotically Tunable Microdroplets Enable Amplification-Free CRISPR Detection of Gene Doping.
Gene doping is an increasing challenge in sports, demanding highly sensitive and specific detection tools beyond the limitations of the current amplification-dependent methods. Here, an innovative amplification-free clustered regularly interspaced short palindromic repeats/CRISPR-associated protein ...
S-EPMC12752553 | biostudies-literature
UnknownNeurological Complications Resulting from Non-Oral Occupational Methanol Poisoning.
Methanol poisoning results in neurological complications including visual disturbances, bilateral putaminal hemorrhagic necrosis, parkinsonism, cerebral edema, coma, or seizures. Almost all reported cases of methanol poisoning are caused by oral ingestion of methanol. However, recently there was an ...
S-EPMC5220007 | biostudies-literature
UnknownA Survey of Perspectives on Telemedicine for Patients With Parkinson's Disease.

Objective

Parkinson's disease (PD) patients often find it difficult to visit hospitals because of motor symptoms, distance to the hospital, or the absence of caregivers. Telemedicine is one way to solve this problem.

Methods

We surveyed 554 PD patients from eight university hospitals ...
S-EPMC10846964 | biostudies-literature
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