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TranscriptomicsTranscription profiling of E. coli K-12 yliH and yceP biofilm expression relative to wild type
Expression in biofilm cells of mutants yceP and yliH relative to biofilm cells of E. coli K-12 wild type strain Experiment Overall Design: All strain cultured in LB glu, biofilm isolated from glass wool after culturing for 24 hrs.
ORGANISM(S): Escherichia coli 
2008-06-12 | E-GEOD-3937 | biostudies-arrayexpress
TranscriptomicsComparison between wild type E. coli and adhE (alcohol dehydrogenase) mutants, grown under anaerobic condition
To characterize anaerobic stress-induced expression in adhE mutants, the microarray experiment was performed with two serotypes of wild type E. coli and their adhE mutants: (1) K-12 strain, wild type; (2) B strain, wild type; (3) BW25113, adhE mutants; (4) BL21(DE3), adhE mutants. Under anaerobic gr...
ORGANISM(S): Escherichia coli BL21(DE3) 
2014-09-26 | E-GEOD-46455 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli K-12 mutants yceP, trpE, and tnaA biofilm cell 24 hr
Gene expression of (i) K-12 yceP biofilms upon addition of 600 µM indole in LB glu medium, (ii) K-12 biofilms due to the trpE mutation in LB glu medium, and (iii) K-12 biofilms due to the tnaA mutation in LB medium. Experiment Overall Design: Strains:E. coli K12 BW25113 delta yceP, trpE, tnaA and w...
ORGANISM(S): Escherichia coli 
2008-06-13 | E-GEOD-4562 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of advanced murine K-RasG12V lung adenocarcinomas
We aimed to analyze the transcriptional profile of full-blown murine lung adenocarcinomas driven by K-RasG12V oncogene. We used a GEM model of lung adenocarcinoma driven by a resident K-RasG12V oncogene. On average, tumors were collected 10 months after Adeno-CRE infection.
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-65257 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of normal lung cells and K-RasG12V driven hyperplasias
We aimed to analyze the transcriptional profile of lung epithelial cells early after the expression of a resident K-RasG12V oncogene. This approach was based on the rationale that valuable therapeutic targets should be easier to detect in the first stages of tumor development due to tumor heterogene...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-65256 | biostudies-arrayexpress
ProteomicsTGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells
DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopit...
ORGANISM(S): Homo sapiens (Human) 
2017-04-07 | PXD005620 | Pride
Dna mismatch repair deficiency Lc-msms Transforming growth factor beta receptor type 2 Colorectal cancer Microsatellite instability Exosomes Proteomics 
TranscriptomicsHoneys Inhibit Virulence and Biofilm Formation in Enterohaemorrhagic Escherichia coli O157:H7, but Do not Harm Commensal Escherichia coli K-12 Biofilm
Honey has been widely used against bacterial infection for centuries. Previous studies suggested that honeys in high concentrations inhibited bacterial growth due to the presence of anti-microbial compounds, such as methylglyoxal, hydrogen peroxide, and peptides. In this study, we found that three...
ORGANISM(S): Escherichia coli 
2012-03-30 | E-GEOD-28193 | biostudies-arrayexpress
TranscriptomicsHoneys Inhibit Virulence and Biofilm Formation in Enterohaemorrhagic Escherichia coli O157:H7, but Do not Harm Commensal Escherichia coli K-12 Biofilm
Honey has been widely used against bacterial infection for centuries. Previous studies suggested that honeys in high concentrations inhibited bacterial growth due to the presence of anti-microbial compounds, such as methylglyoxal, hydrogen peroxide, and peptides. In this study, we found that three h...
ORGANISM(S): Escherichia coli 
2012-03-31 | GSE28193 | GEO
TranscriptomicsTranscription profiling of lung carcinoma and brain glioblastoma cells were analalyzed, with microarrays run both for control and treatment with dichloroacetate reveals a mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis inhibits cancer growth
The unique metabolic profile of most cancers (aerobic glycolysis) might confer apoptosis-resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential and low expression of the K+ channel Kv1.5, both contributing to apoptosis-r...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6014 | biostudies-arrayexpress
UnknownImiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels.
Not available
S-EPMC3292985 | biostudies-literature
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