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TranscriptomicsTranscription profiling of human peripheral blood lymphocytes: comparison between melanoma patients and healthy controls
We focused on the major peripheral blood lymphocyte populations that may be involved in anti-tumor responses and negatively impacted by cancer, specifically CD8 T cells, CD4 T cells, B cells and CD56dim natural killer cells. The pure cell subsets were stringently sorted by flow cytometry from PBMC s...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6887 | biostudies-arrayexpress
TranscriptomicsRNA_Pol2_Ser5phospho_mES
Mouse embryonic stem cells were used to study RNA Polymerase 2 phosphorylation of Ser 5 IP. Duplicate whole genome mouse arrays of embryonic stem cells. RNA Polymerase II phosphoCTD (Serine 5) antibody was used in the experiment.
ORGANISM(S): Mus musculus 
2011-10-03 | E-GEOD-17273 | biostudies-arrayexpress
TranscriptomicsGastric Cancer Subtyping (Australian Patient Cohort)
Genome-wide mRNA expression profiles of 70 primary gastric tumors from the Australian patient cohort. Like many cancers, gastric adenocarcinomas (gastric cancers) show considerable heterogeneity between patients. Thus, there is intense interest in using gene expression profiles to discover subtypes ...
ORGANISM(S): Homo sapiens 
2012-07-04 | E-GEOD-35809 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
UnknownPlasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib.
Not available
S-EPMC8107763 | biostudies-literature
TranscriptomicsImmune and tumor cell gene expression from node positive and node negative breast cancers' primary tumor, lymph nodes and peripheral blood
Analysis of purified immune and breast tumor cells from three major compartments where cancer and immune cells interact: primary tumor, tumor draining lymph nodes (tumor invaded or tumor free), and peripheral blood. The results suggests that node-positive patients’ immune regulation and functionali...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-41986 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [mouse]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-30406 | biostudies-arrayexpress
TranscriptomicsMapping Clinical and Expression QTL in a Sex-Dependent Effect of Host Susceptibility to Influenza H3N2/HK/1/68-MA20
Seasonal influenza outbreaks and recurrent influenza pandemics present major challenges to public health. By studying immunological responses to influenza in different host species, it may be possible to discover common mechanisms of susceptibility in response to various influenza strains. This coul...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35888 | biostudies-arrayexpress
TranscriptomicsISL1, a Regulator of Adipocyte Differentiation of Potential Importance in Visceral Fat
Visceral fat (VF) and subcutaneous fat (SF) are developmentally different tissues with different gene expression. Islet-1 (ISL1), a LIM-homeobox transcription factor with important developmental and regulatory function in islet, neural, and cardiac tissue, is virtually absent in SF but substantially...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-40565 | biostudies-arrayexpress
TranscriptomicsAgilent 244A aCGH array for comparison of lung tumor CNA to high-throughput sequencing data
1 lung tumor was profiled for copy-number alterations with the high-resolution Agilent 244A aCGH Array. One lung tumor sample were assayed on the Agilent Human Genome CGH 244A Microarrays with the intent of comparing the genomic alterations reported by the array platform with those reported by high-...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-20574 | biostudies-arrayexpress
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