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UnknownR-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.
Not available
S-EPMC10922727 | biostudies-literature
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
TranscriptomicsTranscriptome profiling of knock mutant and RNAi lines for small GTPase, nucleolar GTP-binding protein 1 (NOG1) in Arabidopsis
Gene expression profiling of knock out mutant NOG1-1 and RNAi line NOG1-2 was studied in comparison to wild type in leaves of seven days old plants.
ORGANISM(S): Arabidopsis thaliana 
2017-07-19 | E-MTAB-5946 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficiency on unstimulated A549 cells
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35265 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during infection with H1N1 influenza A virus or vesicular stomatitis virus (VSV)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35266 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during stimulation with PR8/∆NS1 influenza virus, IFNβ1 or Poly(I:C)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35267 | biostudies-arrayexpress
Proteomics,MultiomicsHs_NSCLC_Phospho
This is a large-scale survey of tyrosine kinase activity in lung cancer. Tyrosine kinase signaling across 41 non-small cell lung cancer (NSCLC) cell lines and over 150 NSCLC tumors are characterized Using a phosphoproteomic approach.
ORGANISM(S): Homo Sapiens (human) 
2007-12-31 | PAe005321 | PeptideAtlas
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells
This SuperSeries is composed of the following subset Series: GSE35265: Analysis of global gene expression profiles of hPAF1 deficiency on unstimulated A549 cells GSE35266: Analysis of global gene expression profiles of hPAF1 deficient A549 cells during infection with H1N1 influenza A virus or vesicu...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35268 | biostudies-arrayexpress
Genomics32c6825c-80c0-4d0f-9284-cc7c1a39e68a - samples
Whole transcriptome sequencing (RNA-seq) was performed on 39 PC specimens. Among them, 21 specimens also had WES data.
EGAD00001004365 | EGA
Genomicsc9d38693-41de-4186-90c3-5e52d1913254 - samples
Whole-exome sequencing (WES) was performed on a total of 34 PC specimens, with 15 cases having matched gDNAs extracted from blood.
EGAD00001004364 | EGA
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