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UnknownThree-dimensional regulatory hubs support oncogenic programs in glioblastoma.
Not available
S-EPMC11875237 | biostudies-literature
TranscriptomicsIn embryo analysis of H3K27 trimethylation suggests a two-step process involving PRC2 interacting sequences and high GC content
ABSTRACT Polycomb group (PcG) proteins are essential for the repression of key developmental regulators during development. In Drosophila, the polycomb repressive complexes (PRC) associate with defined DNA sequences termed polycomb response elements (PREs). In mammals, however, the mechanisms under...
ORGANISM(S): Mus musculus 
2015-01-27 | E-GEOD-43915 | biostudies-arrayexpress
TranscriptomicsBase and acid resistance of B. subtilis associated with transcriptomic responses
Gene expression profiles of Bacillus subtilis strain AG174 were compared as a function of steady-state external pH during growth with aeration. Aerated overnight cultures were diluted 1:500 and incubated in 250 mL baffled flasks containing potassium-modified Luria-Bertani medium (LBK) buffered with ...
ORGANISM(S): Bacillus subtilis 
2009-01-12 | E-GEOD-11810 | biostudies-arrayexpress
GenomicsH2A.Z (pht1) ChIP-seq data in 968, Y0036, and swc5-del strains
After finding a QTL hotspot in a fission yeast cross of strains 968xY0036 that was apparently driven by frame shift mutation in swc5 (swc5-fs), we have determined the genome-wide occupancy of the histone variant H2AZ (PhT1). Indeed swc5 has been shown to affect H2AZ occupancy. To test the impact of ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2650 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung carcinoma and brain glioblastoma cells were analalyzed, with microarrays run both for control and treatment with dichloroacetate reveals a mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis inhibits cancer growth
The unique metabolic profile of most cancers (aerobic glycolysis) might confer apoptosis-resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential and low expression of the K+ channel Kv1.5, both contributing to apoptosis-r...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6014 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of 968xY0036 fission yeast recombinant library
We generated the first recombinant strain library for fission yeast and conducted an RNA-seq based QTL study of the coding, non-coding, and antisense transcriptomes. We cross the lab strain 968 with the lab strain Y0036 to generate segregant. We used RNA-seq for both expression profiling and gentoyp...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2640 | biostudies-arrayexpress
TranscriptomicsMetronomic doxorubicin blocks HIF-1α-mediated responses in sarcomas and augments the effects of anti-VEGF-A therapy
Increased levels of hypoxia and hypoxia inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged anti-angiogenic therapy of tumors can delay tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatm...
ORGANISM(S): Homo sapiens 
2011-08-29 | E-GEOD-31715 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 57 hepato cellular carcinoma tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 65 samples on Affymetrix HG-U133A GeneChips arrays (57 tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools). Identification of six subgroups of Hepatocellular...
ORGANISM(S): Homo sapiens 
2007-03-26 | E-TABM-36 | biostudies-arrayexpress
TranscriptomicsWee1 Inhibition sensitizes prostate cancer cells to Hsp90 inhibitor to activate the intrinsic apoptotic pathway
Heat shock protein 90 (Hsp90) is an essential evolutionarily conserved molecular chaperone in eukaryotes. Cancer cells rely on Hsp90 to chaperone activated oncoproteins, and its involvement in numerous signaling pathways makes it an attractive target for drug development. Surprisingly, however, the ...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-38972 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of Ovis aries
We have completed the high quality reference genome for domestic sheep (Oar v3.1) and performed a detailed survey of gene expression across different tissues. RNA-seq data of 7 tissue types from the reference female Texel and skin tissue from a Gansu alpine fine wool sheep were sequenced. Here is t...
ORGANISM(S): Ovis aries 
2014-06-06 | E-GEOD-56643 | biostudies-arrayexpress
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