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ProteomicsAn in situ ascorbate peroxidase 2-based labeling method and its application in detecting exosome proteins released from mouse proximal tubule cells under oxidative stress
Here, we developed an in situ labeling approach to identify exosome-loaded proteins, which bypasses the traditional exosome isolation steps. In this method, an engineered ascorbate peroxidase targeting to endosomes-destined exosomes was used to label proteins loaded inside exosomes released from kid...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD025852 | Pride
Apex2 Kidney Mouse Oxidative stress Exosomes Lc-ms/ms 
ModelsHong2004 - Genome-scale metabolic network of Mannheimia succiniciproducens (iSH335)
Hong2004 - Genome-scale metabolic network of Mannheimia succiniciproducens (iSH335) This model is described in the article: The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens. Hong SH, Kim JS, Lee SY, In YH, Choi SS, Rih JK, Kim CH, Jeong H, Hur...
2015-07-30 | MODEL1507180025 | BioModels
MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
ProteomicsVutiglabridin ameliorates obesity by directly reducing fat mass through AMPK/lipophagy activation in adipocytes
Current anti-obesity therapies that suppress appetite often cause undesirable reductions in lean mass by indirectly depleting systemic energy store. In this study, we developed a novel anti-obesity drug, Vutiglabridin (VUTI), designed to selectively reduce fat mass while preserving lean mass. We eva...
ORGANISM(S): Mus Musculus (mouse) 
2026-04-30 | PXD069901 | JPOST Repository
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