Sort   by:  
 Page size 
TranscriptomicsA high dimensional deep sequencing study of non-small cell lung adenocarcinoma in never-smoker Korean females
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-37765 | biostudies-arrayexpress
UnknownRapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology.
In vitro prediction of the probable rapid emergence of resistance to a drug in tumors could act to winnow out potential candidates for further costly development. We have developed a microfluidic device consisting of ∼500 hexagonal microcompartments that provides a complex ecology with wide ranges o...
S-EPMC5167174 | biostudies-literature
UnknownAn integrated clinical and genomic information system for cancer precision medicine.
BACKGROUND:Increasing affordability of next-generation sequencing (NGS) has created an opportunity for realizing genomically-informed personalized cancer therapy as a path to precision oncology. However, the complex nature of genomic information presents a huge challenge for clinicians in interpreti...
S-EPMC5918454 | biostudies-literature
GenomicsA high dimensional deep sequencing study of non-small cell lung adenocarcinoma in never-smoker Korean females [Seq]
One of the most fertile applications of next generation sequencing will be in the field of cancer genomics. Here, we report a high-throughput multi-dimensional sequencing study of primary non-small cell lung adenocarcinoma tumors and adjacent normal tissues of 6 never-smoker Korean female patients. ...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-37764 | biostudies-arrayexpress
TranscriptomicsA high dimensional deep sequencing study of non-small cell lung adenocarcinoma in never-smoker Korean females [aCGH]
One of the most fertile applications of next generation sequencing will be in the field of cancer genomics. Here, we report a high-throughput multi-dimensional sequencing study of primary non-small cell lung adenocarcinoma tumors and adjacent normal tissues of 6 never-smoker Korean female patients. ...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-37759 | biostudies-arrayexpress
UnknownProprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells.
Previously we demonstrated that Ahnak mediates transforming growth factor-β (TGFβ)-induced epithelial-mesenchymal transition (EMT) during tumor metastasis. It is well-known that circulating tumor cells (CTCs) invade the vasculature of adjacent target tissues before working to adapt to the host envir...
S-EPMC8350332 | biostudies-literature
UnknownConserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells.
Endothelial dysfunction and inflammatory immune response trigger dedifferentiation of vascular smooth muscle cells (SMCs) from contractile to synthetic phenotype and initiate arterial occlusion. However, the complex vascular remodeling process playing roles in arterial occlusion initiation is largel...
S-EPMC9918535 | biostudies-literature
UnknownFCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress.
In this study, we report a novel function of FCN3 (Ficolin 3), a secreted lectin capable of activating the complement pathway, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of FCN3 was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and...
S-EPMC8050313 | biostudies-literature
UnknownGlutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling.
Triple-negative breast cancer (TNBC) cells, which do not express genes for estrogen receptor (ER), progesterone receptor (PR), and Her2/neu, develop highly aggressive and metastatic tumors resistant to chemo- and hormonal therapies. We found that expression of glutathione peroxidase-1 (Gpx1) is sile...
S-EPMC6906704 | biostudies-literature
UnknownDissecting transcriptome signals of anti-PD-1 response in lung adenocarcinoma.
Immune checkpoint blockades are actively adopted in diverse cancer types including metastatic melanoma and lung cancer. Despite of durable response in 20-30% of patients, we still lack molecular markers that could predict the patient responses reliably before treatment. Here we present a composite m...
S-EPMC11387489 | biostudies-literature
Sort   by:  
 Page size