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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
TranscriptomicsIdentification of Biofilm Inhibitors from Streptomyces Strains for Reducing Pseudomonas aeruginosa Biofilm Formation
Biofilms are ubiquitous in natural, medical, and engineering environments. While most antibiotics that primarily aim to inhibit cell growth may result in bacterial drug resistance, biofilm inhibitors do not affect cell growth and there is less chance of developing resistance. This work sought to id...
ORGANISM(S): Pseudomonas aeruginosa 
2013-03-21 | E-GEOD-28194 | biostudies-arrayexpress
ProteomicsA mitochondrial proteome profile of type 2 diabetes mellitus in skeletal muscles
The goal of the project is to understand the mitochondrial proteome profiles related to T2DM. We performed comprehensive proteome profiling of mitochondria isolated from skeletal muscles in nine T2DM patients and nine control subjects with normal glucose tolerance (NGT).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083560 | MassIVE
ProteomicsHuman lung adenocarcinoma tissue LC-MS/MS
This project is a report of a chromosome-based human proteome project focused on chromosome 9 (Chr 9). To reveal missing proteins and undiscovered features in proteomes, LC-MS/MS analysis based identification and characterization were conducted on 5 pairs of lung adenocarcinoma tumors and adjacent n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079961 | MassIVE
Unknown[Korean Clinical Imaging Guidelines for the Appropriate Use of Chest MRI].
MRI has the advantages of having excellent soft-tissue contrast and providing functional information without any harmful ionizing radiation. Although previous technical limitations restricted the use of chest MRI, recent technological advances and expansion of insurance coverage are increasing the d...
S-EPMC9432450 | biostudies-literature
UnknownComparison of Iohexol-380 and Iohexol-350 for Coronary CT Angiography: A Multicenter, Randomized, Double-Blind Phase 3 Trial.

Objective

This multi-center, randomized, double-blind, phase 3 trial was conducted to compare the safety and efficacy of contrast agents iohexol-380 and iohexol-350 for coronary CT angiography in healthy subjects.

Materials and methods

Volunteers were randomized to receive 420 mgI/kg ...
S-EPMC4842853 | biostudies-literature
ProteomicsQuantitative proteomic analysis of CKD urine samples
Urinary proteomics studies have primarily focused on identifying markers of chronic kidney disease (CKD) progression. Here, we aimed to specify CKD-related injury markers through proteomics analysis in urine of patients with CKD. Label-free quantitative proteomics analysis based on liquid chromatogr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-15 | MSV000087635 | MassIVE
UnknownRegorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial.

Purpose

We evaluated the activity of regorafenib, an oral multikinase inhibitor, in advanced gastric adenocarcinoma.

Patients and methods

We conducted an international (Australia and New Zealand, South Korea, and Canada) randomized phase II trial in which patients were randomly assign...
S-EPMC5019744 | biostudies-literature
UnknownGenome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs)...
S-EPMC3636649 | biostudies-literature
UnknownAssociations of autozygosity with a broad range of human phenotypes.
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confoundi...
S-EPMC6823371 | biostudies-literature
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