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TranscriptomicsIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
We performed RNAseq on ulcers and distant normal tissue from biopsy-wounded wild-type and Bmp4-overexpressing (Vil1-Cre;Rosa26-Bmp4) mice to investigate differences in gene expression between tissue states and genotypes. Biopsy wounding was performed by taking three biopsies from well-separated area...
ORGANISM(S): Mus musculus 
2021-05-09 | E-MTAB-10238 | biostudies-arrayexpress
TranscriptomicsAblation of Lgr5-positive cells in intestinal polyps from ApcMin;Lgr5DTR mice
We performed RNAseq on intestinal polyps from diptheria toxin-treated ApcMin;Lgr5DTR mice to investigate the effect of an acute selective pressure on stem cell populations in intestinal lesions. Lgr5+ cells in the ApcMin;Lgr5DTR mice were ablated with a single intraperitoneal dose of diphtheria toxi...
ORGANISM(S): Mus musculus 
2022-06-30 | E-MTAB-10470 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse intestinal organoids treated with interferon-gamma
We aimed to investigate gene expression changes in intestinal organoids from different mouse genotypes after treatment with interferon-gamma. Wild-type, villinCreER;KrasG12D/+;Trp53fl/flRosa26N1icd/+ (KPN), and villinCreER;Apcfl/fl;KrasG12D/+;Trp53fl/flTgfbrIfl/fl (AKPT) intestinal organoids were pl...
ORGANISM(S): Mus musculus 
2022-06-30 | E-MTAB-11769 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse intestinal organoids treated with TGF-beta
We aimed to investigate gene expression changes in intestinal organoids from different mouse genotypes after treatment with TGF-beta. Wild-type, villinCreER;KrasG12D/+;Trp53fl/flRosa26N1icd/+ (KPN), and villinCreER;Apcfl/fl;KrasG12D/+;Trp53fl/flTgfbrIfl/fl (AKPT) intestinal organoids were plated, an...
ORGANISM(S): Mus musculus 
2022-06-30 | E-MTAB-11784 | biostudies-arrayexpress
Genomicsena-DATASET-WIMM-10-10-2016-16:24:16:111-38 - samples
Whole Genome Sequencing data set for the study "Premalignant SOX2 in ovarian cancer patients"
EGAD00001002734 | EGA
GenomicsPremalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies
To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). Laser capture microdissection of t...
EGAS00001001909 | EGA
GenomicsOvarian Cancer Laboratory, University of Oxford
Data Access Committee EGAC00001000518
EGAC00001000518 | EGA
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