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TranscriptomicsVreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.
Here, we analyzed small RNA libraries derived from ovarian tissues heterozygous or mutant for the Tudor gene, Vreteno. In the absence of vret, Piwi-bound piRNAs are lost without changes in piRNA precursor transcript production, supporting a role for Vret in primary piRNA biogenesis. In the germline,...
ORGANISM(S): Drosophila melanogaster 
2011-08-15 | E-GEOD-30088 | biostudies-arrayexpress
TranscriptomicsVreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
In Drosophila, Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the germline genome by silencing mobile genetic elements. This defense system acts in germline and gonadal somatic tissue to preserve germline development. Genetic control for these silencing pathways varies great...
ORGANISM(S): Drosophila melanogaster 
2011-09-28 | E-GEOD-30360 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes induced in Mycobacterium by in vitro acid-nitrosative multi-stress
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mycobacterium smegmatis str. MC2 155 
2013-11-05 | E-GEOD-34624 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes induced in Mycobacterium smegmatis by in vitro acid-nitrosative multi-stress
Transcriptional profile of Mycobacterium smegmatis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress. Two-condition experiment, MSMEG-K vs. MSMEG-ACID-NO treated. Biological replicates: 3 controls, 3 Acid-NO treated, independently grown and h...
ORGANISM(S): Mycobacterium smegmatis str. MC2 155 
2013-11-05 | E-GEOD-34622 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of pathogenic and non-pathogenic in vitro generated mycobacterial cell wall deficient forms
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-11-29 | E-GEOD-32237 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes induced by in vitro generated Mycobacterium tuberculosis cell wall deficient forms
Transcriptional profile of chemically generated Mycobacterium tuberculosis cell wall deficient forms, comparing untreated control cells (bacillary forms) and cell wall deficient cells. Two-condition experiment, MTB-K vs. MTB-Sph cells. Biological replicates: 3 controls, 3 spheroplasts, independently...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-11-29 | E-GEOD-32236 | biostudies-arrayexpress
UnknownDe novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder
Not available
S-SCDT-10_1038-S44318-024-00322-Y | biostudies-other
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