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TranscriptomicsDiscovery of the genes controlled by the second messenger cyclic di-GMP in Mycobacterium tuberculosis
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many biological processes in bacteria. The genome in Mycobacterium tuberculosis encodes a single copy of the diguanylate cyclase gene (dgc) responsible for c-di-GMP synthesis. To determine the role of c-di-GMP signaling in M. t...
ORGANISM(S): Mycobacterium tuberculosis 
2013-10-09 | E-GEOD-37973 | biostudies-arrayexpress
TranscriptomicsIdentification of a predictive gene signature to recMAGE A3 antigen-specific cancer immunotherapy in metastatic melanoma and non-small-cell lung cancer
Purpose: To evaluate the presence of a gene expression signature present before treatment as predictive of response to treatment with MAGE‑A3 immunotherapeutic in metastatic melanoma patients and to validate its predictivity in adjuvant therapy of early-stage lung cancer. Patients were participan...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-35640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa overexpressing the ECF sigmas PA0149, PA2050, PA2093 and PA4896 involved in cell-surface signaling systems
Cell-surface signaling is a sophisticated regulatory mechanism used by gram-negative bacteria to sense signals from outside the cell and transmit them into the cytoplasm. This regulatory system consists of an outer membrane-localized TonB-dependent receptor (TonB-dependent transducer), a cytoplasmic...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-16 | E-GEOD-9657 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of IDH1mut in the sorted mouse bone marrow cells
Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-45019 | biostudies-arrayexpress
MetabolomicsNew insights into the responses of soil microorganisms to polycyclic aromatic hydrocarbon stress by combining enzyme activity and sequencing analysis with metabolomics
Polycyclic aromatic hydrocarbons (PAHs), some of the most widespread organic contaminants, are highly toxic to soil microorganisms. Whether long-term polluted soils can still respond to the fresh input of pollutants is unknown. In this study, the soil enzyme activity, soil microbial community struct...
2021-02-17 | MTBLS1196 | MetaboLights
UnknownLoss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.
Not available
S-EPMC7080761 | biostudies-literature
UnknownProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
Not available
S-EPMC5920066 | biostudies-literature
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