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TranscriptomicsMode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus
Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against gram-positive bacteria. The minimal inhibitory concentrations ranged from 0.31 µg/ml against community-acquired methicillin resista...
ORGANISM(S): Staphylococcus aureus 
2011-01-04 | E-GEOD-23077 | biostudies-arrayexpress
TranscriptomicsMetabolic modeling of antibiotic and cytotoxic effects of the isoquinoline IQ-238 in S. aureus, S. epidermidis and human cells
Isoquinolines (IQs) are natural substances with antibiotic potential. IQ-238 is a synthetic analog of the novel-type N,C-coupled naphtylisoquinoline (NIQ) alkaloid ancisheynine. Gene expression data, cytotoxicity measurements and metabolic modelling is combined to assess the effects of the N,C-coup...
ORGANISM(S): Staphylococcus aureus 
2015-04-30 | E-GEOD-33832 | biostudies-arrayexpress
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