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UnknownThe detection of a strong episignature for Chung-Jansen syndrome, partially overlapping with Borjeson-Forssman-Lehmann and White-Kernohan syndromes.
Not available
S-EPMC11186873 | biostudies-literature
ProteomicsDiscovering biomarkers for non-alcoholic steatohepatitis pa-tients with and without hepatocellular carcinoma using fecal metaproteomics
High-calorie diets lead hepatic steatosis and to the development of non-alcoholic fatty liver disease (NAFLD), which can evolve over many years into the inflammatory form non-alcoholic steatohepatits (NASH) posing a risk for the development of hepatocellular carcinoma (HCC). Due to the diet and the ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034175 | Pride
Non-alcoholic steatohepatitis Metaproteomics Hepatocellular carcinoma Fecal microbiota Ma-chine learning 
TranscriptomicsProfiling of p53-responsive genes in human breast cancer cells harboring endogenous ts-p53 E285K
The ts-p53 E285K protein is a rare p53 mutant with temperature-sensitive (ts) loss of function characteristics. In cancer cells, which express ts-p53 E285K intrinsically, endogenous wild type p53 activity is reconstituted by appropriate cultivation temperature (permissive condition). At non-appropri...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35006 | biostudies-arrayexpress
MetabolomicsGroundwater metabolome responds to recharge in fractured sedimentary strata

Understanding biogeochemical conversions of dissolved organic matter (DOM) in aquifers is paramount for the effective management of groundwater supplies. On its passage through the critical zone, DOM is subject to biogeochemical conversions and therefore carries cross-habitat information useful f...

2022-03-21 | MTBLS3450 | MetaboLights
UnknownOrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning.
Not available
S-EPMC11440938 | biostudies-literature
MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
UnknownEquine Herpesvirus 1 Multiply Inserted Transmembrane Protein pUL43 Cooperates with pUL56 in Downregulation of Cell Surface Major Histocompatibility Complex Class I.
Not available
S-EPMC4474290 | biostudies-literature
TranscriptomicsCAL-51 breast cancer side population cells
Human solid tumors contain rare cancer side population (SP) cells, which expel the fluorescencent dye H33342 and display cancer stem cell characteristics. Transcriptional profiling of cancer SP cells isolated by H33342 fluorescence analysis is a newly emerging approach to discover cancer stem cell m...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-18773 | biostudies-arrayexpress
MetabolomicsAspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primary aspartate aminotransferase of M. tuberculosis...

2020-05-01 | MTBLS1559 | MetaboLights
UnknownSafety and immunogenicity of MAGE-A3 cancer immunotherapeutic with dacarbazine in patients with MAGE-A3-positive metastatic cutaneous melanoma: an open phase I/II study with a first assessment of a predictive gene signature.
Not available
S-EPMC5687540 | biostudies-literature
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