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ProteomicsSuboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants
Validation of activation of RQC in U34 tRNA modification mutants by identification of ubiquitination of ribosomal proteins uS3 and uS10.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-12-29 | PXD066757 | Pride
Trna modification  ribosome profiling  protein aggregates  protein homeostasis  ribosome-associated quality control  chaperones  integrated stress response  mrna translation  codon pairs  codon optimality 
ProteomicsThiocarboxylation of Urm1 is regulated by tightly-controlled biochemical checkpoints
Ubiquitin related modifier 1 (Urm1) is a highly conserved member of the Ubiquitin-like (UBL) family of proteins. Urm1 is a key component of the eukaryotic thiolation cascade, which is responsible for introducing sulfur at U34 in several eukaryotic tRNAs. Like other UBLs, Urm1 is also able to conjuga...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-02-22 | MSV000094152 | MassIVE
ProteomicsE2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Posttranslational modifications by ubiquitin-like proteins (UBL) are essential for nearly all cellular processes. Ubiquitin related modifier 1 (Urm1) is a non-canonical UBL which plays a key role in tRNA anticodon thiolation as a sulfur carrier protein (SCP). While Urm1 has also been observed to con...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088390 | MassIVE
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