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MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
TranscriptomicsMetabolic Reprogramming During Purine Stress in the Protozoan Pathogen Leishmania donovani
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment. However, little is known about the molecular mechanisms underlying the parasite response to environmental changes, such as nutrient availability....
ORGANISM(S): Leishmania donovani 
2014-02-01 | E-GEOD-48394 | biostudies-arrayexpress
MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
TranscriptomicsComparison of gene expression of miltefosine responsive Vs miltefosine unresponsive Leishmania donovani promastigotes
The current study aims to study change in gene expression profile of miltefosine resistance L. donovani with respect to miltefosine responsive L. donovani. Agilent one-color experiment,Organism: Leishmania donovani, Microarray GeneExpression 8x15k designed by Genotypic Technology Private Limited. (A...
ORGANISM(S): Leishmania donovani 
2013-08-05 | E-GEOD-45496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages infected with Leishmania major or Leishmania donovani
Murine bone marrow derived macrophages were infected with Leishmania major or Leishmania donovania promastigotes, allowed to phagocytose latex beads or not treated. Gene expression profiles were compared to identify i) the effect of Leishmania infection; ii) the differences in effects between L. maj...
ORGANISM(S): Mus musculus 
2008-02-05 | E-MEXP-1254 | biostudies-arrayexpress
TranscriptomicsOverall gene expression comparison between antimony resistant and sensitive Leishmania donovani
The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani. The antimony resistant and sensitive Leishmania donovani were grown in complete M199 medium with 10% FCS and Penicillin streptomycin mixture. At stationary ph...
ORGANISM(S): Leishmania donovani 
2016-07-03 | E-GEOD-62468 | biostudies-arrayexpress
MetabolomicsMultiplatform mass spectrometry-based analysis of Leishmania donovani infected macrophages at different time points after infection
Not available
ORGANISM(S): Homo sapiens + Leishmania donovani 
ST002285 | MetabolomicsWorkbench
TranscriptomicsRAP1A signaling in Leishmania donovani infected macrophages
Monastrol treatment of Leishmania donovani infected macrophages Macrophages were infected with Leishmania donovani and treated with monastrol to look for signalling molecules
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-29246 | biostudies-arrayexpress
MetabolomicsTranscriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms can adopt a quiescent physiological condition which acts as a survival strategy under unfavourable conditions. Quiescent cells are characterized by slow or non-proliferation and deep down-regulation of processes related to biosynthesis. Although quiescence has been described mostly...

2022-02-23 | MTBLS4046 | MetaboLights
ProteomicsMoving from unsequenced to sequenced genome: reanalysis of the proteome of Leishmania donovani
The kinetoplastid protozoan parasite, Leishmania donovani, is the causative agent of kala azar or visceral leishmaniasis. Kala azar is a severe form of leishmaniasis that is fatal in the majority of untreated cases. Studies on proteomic analysis of L. donovani thus far have been carried out using ho...
ORGANISM(S): Leishmania donovani 
2016-12-14 | PXD004338 | Pride
Protoemics and proteogenomics Leishmania donovani 
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