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TranscriptomicsAnalysis of genome rearrangements in S. cerevisiae strains with low levels of DNA polymerase alpha
The arrays in this series were used to analyze chromosome rearrangements resulting from the repair of double-strand breaks at fragile site 2 (FS2) on S. cerevisiae chromosome III. This site is broken under conditions of low DNA polymerase alpha, as described in Lemoine et al., Cell vol. 120, pp. 58...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-16502 | biostudies-arrayexpress
TranscriptomicsCGH detection of chromosomal rearrangements in diploid yeast cells exposed to ionizing radiation
At the organismal level, genome rearrangements are usually deleterious and are often associated with disease. Yet, on an evolutionary scale, they can be beneficial as they provide for rapid genetic diversification. DNA lesions, particularly double-strand breaks (DSBs), are sources of genome instab...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-6984 | biostudies-arrayexpress
TranscriptomicsUsing tiling arrays to precisely detect DNA targets of THO in yeast
Crosslinked DNA from wild type cells or from mutant of the THO complex was analyzed by tiling arrays to precisely detect DNA targets of THO in yeast. DNA coming from SDS-washed DCF pellet and the supernatant SN2k of 2 strains were compared in the study, WT (W303) and mft1 delta (DLY224). The DNA of ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-24 | E-GEOD-32980 | biostudies-arrayexpress
TranscriptomicsBand-array detection of chromosomal rearrangements in diploid yeast cells exposed to ionizing radiation
At the organismal level, genome rearrangements are usually deleterious and are often associated with disease. Yet, on an evolutionary scale, they can be beneficial as they provide for rapid genetic diversification. DNA lesions, particularly double-strand breaks (DSBs), are sources of genome instab...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-6991 | biostudies-arrayexpress
UnknownThe Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats.
Not available
S-EPMC4576514 | biostudies-literature
TranscriptomicsComparative Genomic Hybridization between S. cerevisaie strains JAY270 and S288c.
The arrays in this series correspond to a comparative genomic analysis between S. cerevisiae strain JAY270 and the reference laboratory strain S288c. JAY270 is a heterothalic diploid used in bioethanol production from sugar cane feedstock in Brazil. This strain has several chromosomal length polymor...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-06 | E-GEOD-14601 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis for 29 pancreatic ductal adenocarcinoma (PDAC) samples
Background/Aims: Microarray-based comparative genomic hybridisation (CGH) has allowed high-resolution analysis of DNA copy number alterations across the entire cancer genome. Recent advances in bioinformatics tools enable us to perform a robust and highly sensitive analysis of array CGH data and fac...
ORGANISM(S): Homo sapiens 
2008-12-16 | E-GEOD-9672 | biostudies-arrayexpress
UnknownElevational Changes in Bacterial Microbiota Structure and Diversity in an Arthropod-Disease Vector.
Not available
S-EPMC9622521 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation to identify gene-nuclear pore association in wild type and THO mutants of yeast
This work aimed at analysing the genomic loci that are aberrantly docked to the nucleopore in mutants of the THO complex
ORGANISM(S): Saccharomyces cerevisiae 
2008-08-15 | E-TABM-535 | biostudies-arrayexpress
TranscriptomicsChromosome fragility at the expanded GAA/TTC tracks depends on repeat orientation and requires mismatch repair system.
Expansion of triplex-forming GAA/TTC repeats in the first intron of FRDA gene is known to cause Friedreich’s ataxia. Besides FRDA, there are a number of other highly polymorphic GAA/TTC loci in the human genome where the size variations so far were considered to be a neutral event. Using yeast as ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-05-14 | E-GEOD-11425 | biostudies-arrayexpress
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