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ProteomicsLENG8 mediates nuclear retention and degradation of misprocessed mRNAs and noncoding RNAs
Incompletely processed and misprocessed mRNAs as well as numerous noncoding RNAs are retained in the nucleus and often degraded, and defects in this quality control mechanism have been linked to various diseases, including cancer and neurodegeneration. However, the underlying mechanisms remain poorl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD065356 | Pride
Misprocessed rnas Rna nuclear retention Rna degradation Leng8 
GenomicsCharacterization of RNAs bound by THOC1 or LENG8
Characterization of RNAs bound by THOC1 or LENG8
PRJNA718493 | ENA
UnknownLENG8 mediates RNA nuclear retention and degradation in eukaryotes.
Not available
S-EPMC12363940 | biostudies-literature
OtherCharacterization of RNAs bound by THOC1 or LENG8
Given that LENG8 is associated with the THO complex and is required for mRNA processing, we went on to identify specific RNAs that bind LENG8 or THOC1. Therefore, we precipitated GFP-tagged THOC1, LENG8 or control GFP and sequenced their associated RNAs, using deep sequencing (RNA immune-precipitati...
ORGANISM(S): Homo sapiens 
2021-09-28 | GSE171126 | GEO
GenomicsLENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs
LENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs
PRJNA1276448 | ENA
TranscriptomicsLENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs
Quality control is essential for maintaining proper gene expression. For example, aberrantly processed RNAs are retained and degraded in the nucleus, and defects in this process have been linked to various diseases, including cancer and neurodegeneration. However, the underlying mechanisms of RNA nu...
ORGANISM(S): Homo sapiens 
2025-08-18 | GSE299756 | GEO
Genomics
RNA-Seq analysis of whole cell lysates, cytoplasmic and nuclear fractions from LENG8 depleted cells and control cells.
PRJNA1240595 | ENA
Genomics
The transcriptome of Nipponbare and the Leng8-KO line under low-temperature stress at the germination stage
PRJNA1236022 | ENA
ProteomicsMass spectrometry analyses of Strep-LENG8 and Stre-SAC3D1 immunoprecipitations
Mass spectrometry analyses of Strep-LENG8 and Strep-SAC3D1 immunoprecipitations prepared from HEK293 cells
ORGANISM(S): Homo Sapiens 
PXD082111 |
ProteomicsMolecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs1,2, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including protein-coding RNPs, are exported to the cytoplasm, while transcripts within non-functional pA+ RNPs a...
ORGANISM(S): Homo sapiens (Human) 
2026-06-19 | PXD076297 | Pride
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