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ProteomicsBroad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma
Lenvatinib is the FDA-approved targeted drug for advanced hepatocellular carcinoma (HCC), but the efficacy is modest due to drug resistance. Tumor kinome re-wiring governs drug resistance in resistant cancer cells, which is an obstacle for efficient cancer therapy. Therefore, identification the kina...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD038152 | Pride
Beta-catenin Cancer stemness Hcc Cdk6 Lenvatinib 
GenomicsSingle cell RNA sequencing of immune cells from lenvatinib-resistant mouse HCC model after lenvatinib or combined lenvatinib and CDK4/6 inhibitor palbociclib treatment
Single cell RNA sequencing of immune cells from lenvatinib-resistant mouse HCC model after lenvatinib or combined lenvatinib and CDK4/6 inhibitor palbociclib treatment
PRJNA901914 | ENA
GenomicsRNA-seq analysis of lenvatinib-sensitive and lenvatinib-resistant tumor tissues from a subcutaneous HCC mouse model
RNA-seq analysis of lenvatinib-sensitive and lenvatinib-resistant tumor tissues from a subcutaneous HCC mouse model
PRJNA1455594 | ENA
ProteomicsThe p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma
To understand the role of HIF1a in lenvatinib resistance, we conducted label-free quantitative proteome analysis in both control and lenvatinib resistance cell lines. This analysis revealed changes in the proteome due to the lenvatinib resistance, providing a valuable reference for further investiga...
ORGANISM(S): Homo sapiens (Human) 
2024-08-20 | PXD054805 | Pride
Myh9  usp22  hif1a  hepatocellular carcinoma 
ProteomicsThe p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma
To understand the role of HIF1a in lenvatinib resistance, we conducted label-free quantitative proteome analysis in both control and lenvatinib resistance cell lines. This analysis revealed changes in the proteome due to the lenvatinib resistance, providing a valuable reference for further investiga...
ORGANISM(S): Homo Sapiens 
PXD055440 |
GenomicsSyntaxin-6 mediated autophagy confers lenvatinib resistance in hepatocellular carcinoma
Syntaxin-6 mediated autophagy confers lenvatinib resistance in hepatocellular carcinoma
PRJNA1204913 | ENA
GenomicsRNA Sequencing of HCC cells after lenvatinib, gefitinib, and combination treatment
RNA Sequencing of HCC cells after lenvatinib, gefitinib, and combination treatment
PRJNA663315 | ENA
GenomicsRNA-seq data for parental and lenvatinib-resistant HCC cells
RNA-seq data for parental and lenvatinib-resistant HCC cells
PRJNA772933 | ENA
GenomicsLenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma
Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma
PRJNA925209 | ENA
ProteomicsCytoplasm proteins from JHH-7 and lenvatinib-resistant JHH-7
Cytoplasm proteins were isolated from JHH-7 and lenvatinib-resistant JHH-7, and identified by LC-MS/MS analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-09-01 | PXD045035 | JPOST Repository
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