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TranscriptomicsMicroarray experiment to characterise the signalling pathways downstream SUCNR1 activation in murine Neural Stem Cells (NSCs)
This experiment aimed at characterising the signalling pathways downstream SUCNR1 activation in murine Neural Stem Cells (NSCs). To this end, we profiled by microarray the gene expression changes induced by succinate stimulation in both wild type NSCs and GPR91-deficient NSCs.
ORGANISM(S): Mus musculus 
2018-01-01 | E-MTAB-5586 | biostudies-arrayexpress
TranscriptomicsMicroarray experiment of murine macrophages co-cultured with neural stem cells in the presences of LPS
This experiment aimed at characterising the modulatory role of murine induced Neural Stem Cells (iNSCs) and Neural Stem Cells (NSCs) on macrophages (MPs) exposed to LPS in vitro. Naïve MPs were polarized into an M1-like phenotype with LPS, and then co-cultured with 1:1 ratios of iNSCs in a trans-we...
ORGANISM(S): Mus musculus 
2018-01-01 | E-MTAB-5579 | biostudies-arrayexpress
TranscriptomicsExtracellular vesicles from neural stem cells transfer IFN-? via Ifngr1 to activate Stat1 signalling in target cells
The idea that stem cell therapies work only via cell replacement is challenged by the observation of consistent intercellular molecule exchange between the graft and the host. Here we defined a mechanism of cellular signaling by which neural stem/precursor cells (NPCs) communicate with the microenvi...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-33527 | biostudies-arrayexpress
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