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TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
TranscriptomicsA new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis
When making treatment decisions, oncologists often stratify breast cancers into a low-risk group (ER+, low grade); an intermediate-risk group (ER+, high grade); and a high-risk group that includes Her2+ and triple-negative (ER-/PR-/Her2-) tumors. None of the currently available gene signatures corre...
ORGANISM(S): Homo sapiens 
2011-09-28 | E-GEOD-16987 | biostudies-arrayexpress
ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
TranscriptomicsSockeye salmon (Oncorhynchus nerka) from Aniakchak National Monument and Preserve muscle transcriptome
This dataset was gene expression from natural sockeye salmon populations used to test the preservation of coexpression networks that were found in lake whitefish. Here is the abstract of the manuscript:BackgroundM-BM- : A functional understanding of processes involved in adaptive divergence is one o...
ORGANISM(S): Oncorhynchus nerka 
2013-02-01 | E-GEOD-42985 | biostudies-arrayexpress
ProteomicsCancer Cell Extravasation Requires iPlectin Mediated Choreography of MT1-MMP at Invadopodia
Cancer cell extravasation is a key step of the metastatic cascade and an attractive therapeutic opportunity. Early steps in cancer cell extravasation require formation of tentacle-like protrusions called invadopodia that physically breach the endothelial barrier and degrade extracellular matrix (EC...
ORGANISM(S): Homo sapiens (Human) 
2025-03-28 | PXD039276 | Pride
Invadopodia Cancer Protein-protein interactions 
TranscriptomicsTranscription profiling of human oocytes
The identification of genes and deduced pathways from the mature human oocyte can help us better understand oogenesis, folliculogenesis, fertilization, and embryonic development. Human metaphase II oocytes were used within minutes after removal from the ovary, and its transcriptome was compared with...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12034 | biostudies-arrayexpress
UnknownNovel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis.
Not available
S-EPMC4725893 | biostudies-literature
UnknownChronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids.
Not available
S-EPMC11151039 | biostudies-literature
UnknownNanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis.
Not available
S-EPMC9546917 | biostudies-literature
UnknownVasculogenic mimicry in small cell lung cancer.
Not available
S-EPMC5105195 | biostudies-literature
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