Sort   by:  
 Page size 
ProteomicsCancer Cell Extravasation Requires iPlectin Mediated Choreography of MT1-MMP at Invadopodia
Cancer cell extravasation is a key step of the metastatic cascade and an attractive therapeutic opportunity. Early steps in cancer cell extravasation require formation of tentacle-like protrusions called invadopodia that physically breach the endothelial barrier and degrade extracellular matrix (EC...
ORGANISM(S): Homo sapiens (Human) 
2025-03-28 | PXD039276 | Pride
Invadopodia Cancer Protein-protein interactions 
ProteomicsInvadopodia small extracellular vesicles glioblastoma
The therapeutic efficacy of radiotherapy and chemotherapy with temozolomide (TMZ) for glioblastoma (GBM) is currently limited by the augmented invasive abilities of GBM cells that survive treatment, however the underlying mechanisms remain poorly understood. Due to their ability of transporting onco...
ORGANISM(S): Homo sapiens (Human) 
2023-07-24 | PXD031077 | Pride
Therapeutic Glioblastoma Cancer Small extracellular vesicles Invadopodia Radiotherapy 
ProteomicsA proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells
Invadopodia constitute a specialized machinery required for invasive tumor cells to travel through basement membranes and the interstitial matrix, and thus represent a key feature of metastatic cells. Therefore a better understanding of invadopodia biology and characteristics might permit the identi...
ORGANISM(S): Homo sapiens (Human) 
2020-04-24 | PXD015847 | Pride
Actin cytoskeleton Cancer invasion Tks5/sh3pxd2a 
ProteomicsSerine-threonine kinase TAO3 mediated trafficking of endosomes containing the invadopodia scaffold TKS5-alpha promotes cancer invasion and tumor growth
Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening assay to identify kinases whose activity impacts invadopodia formation. Among the top hits selected for further analysis was TAO3, a STE20-l...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD023867 | Pride
Tks5-alpha Taok3 Tao3 Tmt data Invadopodia Endosomes Phosphoproteomics Ptm quantitation Orbitrap fusion 
ProteomicsDeciphering the involvement of the Hippo pathway co - regulators, YAP/TAZ in invadopodia formation and matrix degradation
Invadopodia are adhesive, actin - rich pro trusions , formed by metastatic cancer cells , that degrade the extracellular matrix and facilitate invasion . They support the metastatic cascade by a spatially and temporally coordinated process where by invading cells bind to the matrix , degrade it by s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD034562 | Pride
Prote omic profiling Tks5 Extracellular matrix Yap Hippo pathway I nvadopodia Actin Taz Gelatin degradation Cancer metastasis Mmp14 (mt1 - mmp) Rna sequencing 
UnknownDynamic membrane remodeling at invadopodia differentiates invadopodia from podosomes.
Not available
S-EPMC3153956 | biostudies-literature
ProteomicsE-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer
E-cadherin is known as an epithelial marker often associated with tumour suppressive function. However, several studies revealed that some tumours cells, such as pancreatic cancer cells, with epithelial traits and high E-cadherin expression can undergo metastasis and form secondary tumours. These ob...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD021795 | Pride
Human Lc-msms E-cadherin Cell invasion Invadopodia Pancreatic cancer 
UnknownExtracellular matrix rigidity promotes invadopodia activity.
Not available
S-EPMC2555969 | biostudies-literature
UnknownECM Cross-Linking Regulates Invadopodia Dynamics.
Not available
S-EPMC5883616 | biostudies-literature
ProteomicsTks5 protein Interactome
Tks5 (SH3PXD2A) is essential for the formation of invadopodia – specialized membrane microdomains that are essential for breast cancer cell migration in extracellular matrix (mostly collagen type I) and invasion. Tks5 is a large scaffold protein and its function at invadopodia is believed to come fr...
ORGANISM(S): Homo sapiens (Human) 
2020-07-08 | PXD011632 | Pride
Breast cancer Invadopodia Sh3pxd2a Invasion Tks5 
Sort   by:  
 Page size