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TranscriptomicsTranscription profiling by array of mouse wild type and E-cadherin knockout embryonic stem cells grown with or without cytokine leukemia inhibitory factor
We previously observed that E-cadherin knockout embryonic stem cells do not differentiate in the absence of the cytokine leukemia inhibitory factor (LIF) (Soncin et al., 2009, Stem Cells 27 p2069-2080). This experiment was designed to compare the transcription profile of E-cadherin KO ES cells cultu...
ORGANISM(S): Mus musculus 
2011-06-19 | E-MEXP-2836 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dendritic cells matured by cadherin reveals disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Sele...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9241 | biostudies-arrayexpress
TranscriptomicsAdipocytokines and E-cadherin in colorectal carcinomas
Expression of adipocytokines and glucocorticoid related genes are associated with down regulation of E-cadherin mRNA in colorectal carcinomas
ORGANISM(S): Homo sapiens 
2012-03-30 | E-MTAB-833 | biostudies-arrayexpress
TranscriptomicsParedes_IPATIMUP_Comparison of cell lines derived from BT-20 cells using siRNA to silence E-cadherin and P-cadherin
Gene expression of four cell lines derived from BT-20 cells, namely, BT20 siCtr (E+/P+), BT20 siPcad (E+/P-), BT20 siEcad (E-/P+), and BT20 siEPcad (E-/P-) was compared using Agilent Human GE 4x44k v2 Microarrays and the Agilent One-Color Microarray-Based Gene Expression Analysis protocol (Quick Amp...
ORGANISM(S): Homo sapiens 
2011-10-01 | E-MEXP-3329 | biostudies-arrayexpress
TranscriptomicsEsophageal keratinocyte invasion after loss of E-cadherin and TGF receptor type II
Esophageal cancer is one of the deadliest cancers as patients present at late stages of disease. Frequent gene alterations include the loss of E-cadherin and TGFb receptor type II. The goal of this study was to establish a model of esophageal cancer by introducing dominant-negative mutants of E-cadh...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-19472 | biostudies-arrayexpress
ProteomicsE-cadherin interactome complexity and robustness resolved by quantitative proteomics
E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of adaptors and enzymes associated with it...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD000448 | Pride
E-cadherin  silac  label-free  interactome  cancer 
TranscriptomicsIdentification of novel tissue-specific transcription arising from E-cadherin/CDH1 intron2: a novel protein isoform increases gastric cancer cell invasion and angiogenesis.
E-cadherin, a protein encoded by the CDH1 gene is the dominant epithelial cell adhesion molecule playing a crucial role in epithelial tissue polarity and structural integrity. The progression of 90% or more carcinomas is believed to be mediated by disruption of normal E-cadherin expression, subcellu...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-32540 | biostudies-arrayexpress
TranscriptomicsSynergistic Tumor Suppressor Activity of E-cadherin and p53 in a Conditional Mouse Model for Diffuse-Type Gastric Cancer
BACKGROUND & AIMS: Gastric cancer is the second most frequent cause of death from cancer in the world, diffuse-type gastric cancer (DGC) exhibiting a poor prognosis. Germline mutations of CDH1, encoding E-cadherin, have been reported in hereditary DGCs, and genetic and/or epigenetic alterations of C...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-25302 | biostudies-arrayexpress
GenomicsEP300 genomic binding analysis in MCF7 cells with E-cadherin inhibition using ChIP-seq
This experiment examines the genomic binding of EP300 in MCF7 breast cancer cells after E-cadherin inhibition. Using ChIP-seq, we identified EP300 binding sites in control (cAb-MCF7) and E-cadherin-inhibited (nAb-MCF7) cells. The goal was to understand how EP300's chromatin binding is altered and it...
ORGANISM(S): Homo sapiens 
2025-06-03 | E-MTAB-15109 | biostudies-arrayexpress
ProteomicsE-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer
E-cadherin is known as an epithelial marker often associated with tumour suppressive function. However, several studies revealed that some tumours cells, such as pancreatic cancer cells, with epithelial traits and high E-cadherin expression can undergo metastasis and form secondary tumours. These ob...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD021795 | Pride
Human Lc-msms E-cadherin Cell invasion Invadopodia Pancreatic cancer 
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