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ProteomicsTks5 protein Interactome
Tks5 (SH3PXD2A) is essential for the formation of invadopodia – specialized membrane microdomains that are essential for breast cancer cell migration in extracellular matrix (mostly collagen type I) and invasion. Tks5 is a large scaffold protein and its function at invadopodia is believed to come fr...
ORGANISM(S): Homo sapiens (Human) 
2020-07-08 | PXD011632 | Pride
Breast cancer Invadopodia Sh3pxd2a Invasion Tks5 
ProteomicsProteomic analysis of Tks5 interactome to identify common marker of all types of invadosomes.
Invasion of the extracellular matrix is needed for physiological events such as wound healing but is also required at different stages of the metastatic process. The ability to progress and invade through the extracellular matrix is a characteristic shared by both normal and cancer cells through the...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-26 | PXD046512 | Pride
Invadosomes Nih cells Tks5 Quantitative proteome Translation 
ProteomicsProteomic analysis of Tks5 interactome to identify common marker of all types of invadosomes.
Invasion of the extracellular matrix is needed for physiological events such as wound healing but is also required at different stages of the metastatic process. The ability to progress and invade through the extracellular matrix is a characteristic shared by both normal and cancer cells through the...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD046515 | Pride
Invadosomes Tks5 Quantitative proteome Translation A431 cells 
GenomicsTKS5 mediates the formation of podosome rosettes in pulmonary fibroblasts and promotes fibrosis.
TKS5 mediates the formation of podosome rosettes in pulmonary fibroblasts and promotes fibrosis.
PRJNA912202 | ENA
TranscriptomicsTKS5 mediates the formation of podosome rosettes in pulmonary fibroblasts and promotes fibrosis.
Here we assess the effect of Tks5 knockout on the transcriptome of activated lung fibroblasts. For this purpose we examine TGF-beta treated fibroblasts from wild type and Tks5 KO mice. We show that Tks5 deficiency affects transcriptome of lung fibroblasts leading to the suppression of biological pro...
ORGANISM(S): Mus musculus 
2023-08-28 | GSE220982 | GEO
ProteomicsA proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells
Invadopodia constitute a specialized machinery required for invasive tumor cells to travel through basement membranes and the interstitial matrix, and thus represent a key feature of metastatic cells. Therefore a better understanding of invadopodia biology and characteristics might permit the identi...
ORGANISM(S): Homo sapiens (Human) 
2020-04-24 | PXD015847 | Pride
Actin cytoskeleton Cancer invasion Tks5/sh3pxd2a 
UnknownThe podosome marker protein Tks5 regulates macrophage invasive behavior.
Not available
S-EPMC3240724 | biostudies-literature
UnknownThe Role of TKS5 in Chromosome Stability and Bladder Cancer Progression
Not available
S-EPMC9698602 | biostudies-literature
UnknownTKS5-positive invadopodia-like structures in human tumor surgical specimens.
Not available
S-EPMC6368464 | biostudies-literature
UnknownXB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival.
Not available
S-EPMC4666142 | biostudies-literature
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