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ProteomicsSerine-threonine kinase TAO3 mediated trafficking of endosomes containing the invadopodia scaffold TKS5-alpha promotes cancer invasion and tumor growth
Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening assay to identify kinases whose activity impacts invadopodia formation. Among the top hits selected for further analysis was TAO3, a STE20-l...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD023867 | Pride
Tks5-alpha Taok3 Tao3 Tmt data Invadopodia Endosomes Phosphoproteomics Ptm quantitation Orbitrap fusion 
UnknownA MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
Not available
S-EPMC10866687 | biostudies-literature
TranscriptomicsThe effects of ibuprofen on the transcriptome of a euryhaline fish
Ibuprofen is one of the most commonly detected pharmaceuticals in wastewater effluent; however the effects of ibuprofen on aquatic organisms are poorly understood. This study presents the transcriptome-wide response of the inland silverside, Menidia beryllina, to chronic 14 d exposures to ibuprofen....
ORGANISM(S): Menidia beryllina 
2015-09-01 | E-GEOD-64967 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Danio rerio fast skeletal muscle from fish fed a single satiating meal
The F5 generation of a wild-caught population of zebrafish (Danio rerio) from Mymensingh, Bangladesh, were used in this study. Replicate experiments were carried out with adult male fish aged 9 months. Each group was maintained in a 50L tank at 27M-11.5M-:C and 12:12h dark:light photoperiod and fed...
ORGANISM(S): Danio rerio 
2011-03-11 | E-MEXP-2887 | biostudies-arrayexpress
ProteomicsDelayed effect of early-life exposure to 17-alpha-ethinylestradiol on brain proteome of adult mangrove rivulus fish
PI: Experiments and fish exposures were performed in the laboratory of Frederic Silvestre at the University of Namur (Belgium). Proteomics contact: Proteomics sample preparation and biological mass spectrometry were performed in the laboratory of Prof. Dietmar Kueltz at UC Davis (CA). LC-MS/MS data ...
ORGANISM(S): Kryptolebias Marmoratus (ncbitaxon:37003) 
2018-08-13 | MSV000082814 | MassIVE
TranscriptomicsTime course experiment of 17β-estradiol (E2) treatment in the zebrafish
Transcriptional profiling of zebrafish (Danio rerio) livers comparing control untreated fish with fish treated with estrogen [17β-estradiol (E2)] for different time points (4, 12, 24, 48 hours). For the assay experimental design, RNA from one of three different E2-treated fish (representing three b...
ORGANISM(S): Danio rerio 
2013-06-28 | E-GEOD-45562 | biostudies-arrayexpress
ProteomicsDelayed effect of early-life exposure to 17-alpha-ethinylestradiol on the liver proteome of adult mangrove rivulus fish
LC-MS/MS data obtained from livers of 17 adult mangrove rivulus exposed to different doses of 17-alpha-ethinylestradiol during early development. All fish acclimations, treatments, experimental design, and data anlyses were performed in Frederic Silvestre's laboratory at the University of Namur, Bel...
ORGANISM(S): Kryptolebias Marmoratus (ncbitaxon:37003) 
2018-08-13 | MSV000082815 | MassIVE
TranscriptomicsTranscriptomic effects of endocrine disruptors in zebrafish embryos
The identification of endocrine disruptive properties of chemicals certain to enter the aquatic environment relies on toxicity tests with fish, assessing adverse effects on reproduction and sexual development. The demand for quick, reliable endocrine disruption (ED) assays favored the use of fish em...
ORGANISM(S): Danio rerio 
2014-03-06 | E-GEOD-44263 | biostudies-arrayexpress
ProteomicsDelayed effect of early-life exposure to 17-alpha-ethinylestradiol on the gonad proteome of adult mangrove rivulus fish
LC-MS/MS data obtained from gonads of 17 adult mangrove rivulus exposed to different doses of 17-alpha-ethinylestradiol during early development. All fish acclimations, treatments, experimental design, and data anlyses were performed in Frederic Silvestre's laboratory at the University of Namur, Bel...
ORGANISM(S): Kryptolebias Marmoratus (ncbitaxon:37003) 
2018-08-13 | MSV000082816 | MassIVE
ProteomicsEffect of water emersion on the gill proteome of Mangrove killifish
Gill proteome of Mangrove killifish was compared by LC-MS/MS using 6 biological replicates of fish exposed to emersion stress versus 6 biological replicates kept under water that served as controls. PI: Experiments and fish exposures were performed in the laboratory of Prof. Patricia Wright at the U...
ORGANISM(S): Kryptolebias Marmoratus (ncbitaxon:37003) 
2017-03-15 | MSV000080634 | MassIVE
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