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Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
Model of the Complement System This is the continuous deterministic (ODE) model of the complement system described in the article: Computational and Experimental Study of the Regulatory Mechanisms of the Complement System. Liu B, Zhang J, T...
2024-09-02 | BIOMD0000000303 | BioModels
Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin pathway is responsible for the specification of mesoderm, endoderm, node and ...
ORGANISM(S): Mus musculus 
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