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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
TranscriptomicsEffect of Leptin on Mouse Trophoblast Giant Cells
Leptin, a hormone produced primarily by adipose tissue, plays a role in both energy homeostasis and reproduction, and is required in early pregnancy. Leptin stimulates metalloproteinase activity in cultured human trophoblast and stimulates invasiveness of cultured mouse trophoblast. The goal of th...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-10297 | biostudies-arrayexpress
TranscriptomicsThe Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome Following Infection with E. histolytica.
Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba histolytica than those carrying the mutant R223 allele. We hypot...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-43372 | biostudies-arrayexpress
TranscriptomicsMicroarray transcriptional analysis of leptin signaling knockdown and rescue in 72-hour post fertilization zebrafish
The effects of leptin-A morpholino oligonucleotides and recombinant leptin-A on embryonic zebrafish transcriptome content were evaluated using Affymetrix 1.1 ST gene array strips.
ORGANISM(S): Danio rerio 
2018-04-02 | E-MTAB-6548 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice
We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress
ProteomicsANGPTL4 binds to leptin receptor to regulate ectopic bone formation and fat metabolism
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR (db/db) and leptin (ob/ob) are not identical, and the cause remains unclear. Here, we show that db/db, but not ob/ob mice had defect in tenotomy-induced heterotopic ossification (HO), ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD043087 | Pride
Leptin receptor  angptl4  heterotopic ossification  fat metabolism 
TranscriptomicsTranscription profiling of two human myeloma cells lines incubated with and without leptin
The effect of recombinant leptin (100 ng/ml) on gene expression in two human myeloma cell lines (RPMI 8226 and ANBL-6) were studied in cells incubated with and without leptin for 24 h.
ORGANISM(S): Homo sapiens 
2006-11-27 | E-MEXP-921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ob/ob leptin-treated and ob/ob saline-treated lungs.
We hypothesize that gene expression in the lungs of these differentially-treated mice are divergent thus contributing to the disparity in their phenotypes. More specifically, (1) Effects of Leptin-treatment of ob/ob postnatal mice lungs are known to be volume-dependent from 2 to 10 wks of age, and a...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-10915 | biostudies-arrayexpress
TranscriptomicsExpression data from livers of F2 mice (B57BL/6 X DBA/2) deficient in leptin receptor (db/db)
In several models of obesity-induced diabetes, increased lipid accumulation in the liver has been associated with decreased diabetes susceptibility. For instance, deficiency in leptin receptor (db/db) leads to hyperphagia and obesity in both C57BL/6 and C57BLKS mice but, only on the C57BLKS backgrou...
ORGANISM(S): Mus musculus 
2011-12-29 | E-GEOD-30140 | biostudies-arrayexpress
GenomicsThe Reciprocal activation between Leptin Receptor and Hippo/YAP axis in Triple Negative Breast Cancer Development [RNA-Seq Leptin]
The Reciprocal activation between Leptin Receptor and Hippo/YAP axis in Triple Negative Breast Cancer Development [RNA-Seq Leptin]
PRJNA1478583 | ENA
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