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TranscriptomicsLetrozole (Femara) early and late responses to treatment
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of th...
ORGANISM(S): Homo sapiens 
2010-07-28 | E-GEOD-20181 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human sequential breast cancer biopsies during letrozole treatment
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of th...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5462 | biostudies-arrayexpress
GenomicsSmall RNA-seq of breast tumor biopsies prior to treatment with letrozole or letrozole with bevacizumab
Small RNA-seq of breast tumor biopsies prior to treatment with letrozole or letrozole with bevacizumab
PRJNA596523 | ENA
Transcriptomicsidentification of miRNA differential expression patterns in a new model of acquired letrozole resistance
Since differential miRNA expression patterns associated with acquired AI resistance have been poorly investigated, the aim of this study was to delineate the deregulation of miRNA expression associated with letrozole response failure in a new model of letrozole resistance. For this purpose, we gener...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43766 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human estrogen receptor positive MCF7 cells stably transfected with aromatase gene treated with testosterone, 17 B-estradiol, two aromatase inhibitors (letrozole and anastrozole), and an anti-estrogen (tamoxifen)
Anti-estrogens and aromatase inhibitors are important drugs in the treatment of estrogen-dependent breast cancer. In order to investigate the effects of these drugs on gene expression in breast cancer cells, we treated estrogen receptor-positive MCF-7 cells, stably transfected with the aromatase ge...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2225 | biostudies-arrayexpress
TranscriptomicsMolecular changes in lobular breast cancers in response to endocrine therapy
Invasive lobular cancer (ILC) accounts for approximately 10-15% of breast carcinomas and although it responds poorly to neoadjuvant chemotherapy, it appears to respond well to endocrine therapy. Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples were obtained from 14 ...
ORGANISM(S): Homo sapiens 
2014-08-11 | E-GEOD-55374 | biostudies-arrayexpress
GenomicsPrimary ER-positive Breast Cancer Treated with Neoadjuvant Letrozole
Primary ER-positive Breast Cancer Treated with Neoadjuvant Letrozole
PRJNA272564 | ENA
GenomicsSmall RNA-seq of breast tumor biopsies prior to treatment with letrozole or letrozole with bevacizumab
Biopsies were collected from post-menopausal women with ER+ HER2- breast cancer who were subsequently treated with either letrozole or letrozole plus bevacizumab.
ORGANISM(S): Homo sapiens 
2019-12-19 | GSE142308 | GEO
GenomicPrimary ER-positive Breast Cancer Treated with Neoadjuvant Letrozole

These are tumor biopsies and corresponding normal samples from patients with early stage ER+/HER2- breast cancer who had received the aromatase inhibitor letrozole for 10-21 days prior to surgery.

phs000857 | dbGaP
TranscriptomicsGenome-wide transcriptomic profiles of the lungs of SARS-CoV-2 infected hamsters treated with the CYP19A1 inhibitor letrozole.
Male and female golden hamsters (n = 5 per group) were either control (PBS) treated or infected with SARS-CoV-2 (105 pfu), following treatment with vehicle or the CYP19A1 (aromatase) inhibitor letrozole for 8 consecutive days. At 21 days post infection, animals were sacrificed; subsequently, the lun...
ORGANISM(S): Mesocricetus auratus 
2023-06-30 | E-MTAB-13100 | biostudies-arrayexpress
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