Leukemic stem cells

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IRAK-4 Q293X mutation (1)
These mice have a relatively normal first wave of spermatogenesis but never become fertile. Older animals show increased apoptosis of germ cells, increasing in severity as germ cell stage advances. (1)
Acute Myeloid Leukemia (1)
Megakaryoblastic leukemia (1)

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Single nuclei were captured using the 10x Genomics Chromium Controller. (2)
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UNIPROT ID/AC

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Modelling Approach

Ordinary differential equation model (2)

Study type

Transcription profiling by array (1148)
ChIP-seq (487)
RNA-seq of coding RNA (281)
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Other (85)
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Genotyping by high throughput sequencing (5)
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2013 (395)
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2014 (297)
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2006 (59)
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2003 (8)

Lab affiliation

Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva, and Swiss Cancer Center Leman, Geneva, Switzerland (2)
Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0379 Oslo, Norway (2)
Functional Proteomics, ICR (2)
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China (1)
Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London (1)
1 Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada 2 Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A5, Canada (1)
Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia (1)
Experimental Hematology, University Medical Center Groningen, The Netherlands (1)
Experimental Hematology, University Medical Center Groningen, University of Groningen, The Netherlands (1)
Department of Internal Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany (1)
Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology (1)
Department of Chemistry, University of Rochester, United States (1)
Professor of Pediatrics Children’s Hospital of Philadelphia 3615 Civic Center Blvd Philadelphia, PA 19104 (1)
Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, Lund, Sweden (1)
Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University BMC B12, 22184 Lund, Sweden (1)
Department of precious medicine, University of Campania "L.Vanvitelli", vico L. de Crecchio 8, Naples, Italy (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 3Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)
Department of Proteomics and Signal Transduction MaxPlanck Institute of Biochemistry (1)
Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Vico L. De Crecchio 7, 80138 Napoli, IT (1)
Department for Molecular Systems Biology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany (1)
Department of Laboratory Medicine, Lund University, Sweden (1)
Professor for Stem Cell Aging Faculty of Medicine Friedrich-Schiller-University Jena Erlanger Allee, 07747 Jena; Germany (1)
1The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark; 2Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark; 3Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Denmark (1)
Marseille Proteomics, CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes (1)
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China (1)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (1)
Department of Biochemistry and Biomedical Sciences McMaster University (1)
University of Rome Tor Vergata (1)
Pablo Menéndez, ICREA Research Professor Stem cell biology, developmental leukemia & immunotherapy Lab Josep Carreras Leukaemia Research Institute Associate Professor - School of Medicine - University of Barcelona Carrer casanova 143. Barcelona 08036. Spain Tel. (+34) 932414287 (1)
1. Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom. 2. Department of Haematology, University of Cambridge, Cambridge, United Kingdom. 3.6. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom. (1)

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Transcription profiling of mouse pre-leukemic stem cells and leukemic stem cells

The molecular pathways mediating unlimited self-renewal and alleged drug resistant properties that are believed to be key for maintenance and re-initiation of leukemia during relapse are largely unexplored area. To gain further insights into the potential pathways responsible for the conversion and...

ORGANISM(S): Mus musculus

2011-03-12 | E-MEXP-2618 | biostudies-arrayexpress

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

Internal tandem duplications in the tyrosine kinase receptor FLT3 (FLT3-ITD) are among the most common lesions in acute myeloid leukemia (AML) and there exists a need for new forms of treatment. Using ex vivo drug sensitivity screening, we found that FLT3-ITD+ patient cells are particularly sensitiv...

ORGANISM(S): Homo sapiens (Human)

2020-09-02 | PXD009423 | Pride

Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding.

Not available

S-EPMC4297865 | biostudies-literature

Microarray analysis of YTHDF2-deficient leukemic stem cells

YTHDF2 is overexpressed in a broad spectrum of human acute myeloid leukemias (AML). To study the role of YTHDF2 in leukemia, total RNA from Ythdf2CKO (n=4) and Ythdf2CTL (n=4) leukemic stem cells were used for Affymetrix global gene expression analysis.

ORGANISM(S): Mus musculus

2019-04-05 | E-MTAB-7782 | biostudies-arrayexpress

Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA

CDK6 as key regulator of hematopoietic and leukemic stem cell activation.

The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (HSCs and LSCs) that exceeds its function as cell-cycle regulator. Although hematopoiesis appears regular under s...

ORGANISM(S): Mus musculus

2015-02-20 | E-GEOD-62012 | biostudies-arrayexpress

Clonal Evolution of Pre-Leukemic HSC Precedes Human AML

phs000549 | dbGaP

Transcription profiling of hematopoietic stem cells in the preleukemic phase from wiltype mice and mice deficient in transcription factor PU.1 to identify transcriptional changes preceding malignant transformation

Knockdown of the transcription factor PU.1 (Spi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of PU.1 knockdown hematopoietic stem cells (HSC) in the preleukemic phase by linear amplification and genome-wide array analysis to identify transcriptional changes precedin...

ORGANISM(S): Mus musculus

2007-11-22 | E-GEOD-5654 | biostudies-arrayexpress

Comparison of normal mouse hematopoietic stem cells (HSC) to mobilized and leukemia-inducing hematopoietic stem cells

Highly purified Hematopoietic stem cells (HSC) from mouse bone marrow (BM) were compared to HSC after two days of cytoxan/GCSF treatment (Cyclophosphamide/granulocyte colony-stimulating factor) (Day2Mob) and leukemic HSC from mice lacking JunB. See Forsberg et. al. 2010 for details. CML - chronic my...

ORGANISM(S): Mus musculus

2010-02-16 | E-GEOD-20359 | biostudies-arrayexpress

Transcription profiling of human acute myelogenous leukemia stem cells reveals disregulated gene networks

We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of L...

ORGANISM(S): Homo sapiens

2009-08-12 | E-GEOD-17054 | biostudies-arrayexpress

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