Leukemogenesis - OmicsDI

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Molecular Leukemogenesis Group, German Cancer Research Center, Heidelberg, Germany Heidelberg University, Medical Faculty, Heidelberg, Germany, 6Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany (3)
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1Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands (1)
1Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA (1)
1Laboratory of Cytometry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 3Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)
Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany Bioanalytics, Georg August University, Robert-Koch-Straße 40, 37073 Göttingen, Germany (1)
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Department of pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China (1)
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Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal (1)
Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France (1)
Laboratory of Cytometry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland (1)
Max Planck Institute of Biophysics and Max Planck Institute for Brain Research (1)
Northwestern University Proteomics Core (1)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (1)
Pablo Menéndez, ICREA Research Professor Stem cell biology, developmental leukemia & immunotherapy Lab Josep Carreras Leukaemia Research Institute Associate Professor - School of Medicine - University of Barcelona Carrer casanova 143. Barcelona 08036. Spain Tel. (+34) 932414287 (1)
Pediatric Hematology, Oncology and Hemostaseology, Hospital for Children and Adolescents, University Hospital of Frankfurt/Main, Goethe-University Frankfurt/Main, Frankfurt, Germany (1)
Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University (1)
Proteomic Hematology Division of Molecular Hematology Lund Stem Cell Center, Lund University BMC B12, 221 84 Lund, Sweden (1)
Proteomic Mass Spectrometry Wellcome Trust Sanger Institute United Kingdom (1)
Quantitative proteomics and metabolomics Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association Hannoversche Str. 28, 10115 Berlin (1)

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Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.

A global view of PML-RAR? transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RAR? transcription factor that is the initiating event of ...

ORGANISM(S): Homo sapiens

2008-09-06 | E-GEOD-12641 | biostudies-arrayexpress

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (RRBS)

The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells, and Dnmt3b has recently been shown to play a role in genic methylation. Forced Dnmt3b expression induced widespread DNA hypermethylation in myc-bcl2 induced leukemias, especially at promoters ...

ORGANISM(S): Mus musculus

2016-01-11 | E-GEOD-71039 | biostudies-arrayexpress

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

2016-01-11 | E-GEOD-71041 | biostudies-arrayexpress

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (expression)

Here, we analyzed global gene expression changes that were associated with over expression of Dnmt3b in MLL-AF9 induced leukemias using the Affymetrix microarray platform. Changes in global gene expression were determined with Affymetrix microarrays in MLL-AF9 induced leukemias over expressing Dnmt3...

ORGANISM(S): Mus musculus

2016-01-11 | E-GEOD-71040 | biostudies-arrayexpress

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (Affymetrix)

DNA methylation is tightly regulated throughout mammalian development and altered methylation patterns are a hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in acute myeloid leukemia (AML) and has been suggested to protect CpG islands and promoters from aberrant methyla...

ORGANISM(S): Mus musculus

2015-04-22 | E-GEOD-59586 | biostudies-arrayexpress

The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response

Increased expression of a set of homeodomain transcription factors, including HoxA10A, characterizes an adverse prognosis subtype of acute myeloid leukemia (AML). This increase in Hox expression may be found in AML with KMT2A or MYST3/CREBBP gene rearrangements, or with normal cytogenetics. Previous...

ORGANISM(S): Homo sapiens (Human)

2025-08-25 | PXD060787 | Pride