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ModelsLevchenko2000_MAPK_Scaffold
MAPK cascade on a scaffold Citation Levchenko, A., Bruck, J., Sternberg, P.W. (2000) .Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci...
2024-09-02 | BIOMD0000000014 | BioModels
ModelsLevchenko2000_MAPK_noScaffold
MAPK cascade in solution (no scaffold) Description This model describes a basic 3- stage Mitogen Activated Protein Kinase (MAPK) cascade in solution. This cascade is typ...
2024-09-02 | BIOMD0000000011 | BioModels
TranscriptomicsGene expression changes in the intestinal crypts of mice with loss of imprinting
To identify genes differentially expressed in the intestinal crypts between LOI(+) and LOI(-) mice, we performed microarray experiments using RNA extracted from laser capture microdissection, by microdissecting an average of 8,000 crypts from each of 3 LOI(+) and 3 LOI(-) mice. Keywords: genetic mo...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8583 | biostudies-arrayexpress
ModelsODea2007_IkappaB
O'Dea, E.L., Barken, D., Peralta, R.Q., Tran K.T., Werner, S.L., Kearns, J.D., Levchenko, A., Hoffmann, A. A homeostatic model of IkB metabolism to control constitutive activity. Molecular Systems Biology, 3:111, pp. 1-7. 2007 Questions concerning the paper should be addressed to the corresp...
2024-09-02 | BIOMD0000000147 | BioModels
ModelsODea2007 - A homeostatic model of IκB metabolism to control constitutive NF-κB activity
Insert Citation Questions concerning the paper should be addressed to the corresponding author. Alexander Hoffmann (ahoffmann@ucsd.edu) The original model was written and simulated within MathWorks MatLab 2006a using the ode15s (stiff/NDF) solver. It is highly recommended...
2019-08-27 | MODEL1908270002 | BioModels
ModelsHoffmann2002_WT_IkBNFkB_Signaling
This model corresponds to the IkB-NFkB signaling in wild type cells and reproduces the dynamics of the species as depicted in Figure 2 F of the paper. The authors mention that the simulation is carried out in three phases, where the steady state values of the species in one phase are fed to the suc...
2024-09-02 | BIOMD0000000140 | BioModels
ModelsHoffmann2002_KnockOut_IkBNFkB_Signaling
The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species that are not present must be set to zero and the rate of the one that is present must be set as seven ...
2024-09-02 | BIOMD0000000139 | BioModels
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