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GenomicsGenome-wide maps of nucleosome occupancy in human lymphoblastoid cell lines
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to assess due to the limited resolution of existing ...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-36979 | biostudies-arrayexpress
GenomicsIdentification of genetic variants that affect histone modifications in human cells
Histone modifications are important markers of function and chromatin state, yet the DNA elements that direct them to specific locations in the genome are poorly understood. Here we use the genetic variation in Yoruba lymphoblastoid cell lines as a natural experiment to identify genetic differences ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-47991 | biostudies-arrayexpress
TranscriptomicsThe contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels
Analysis of the extent to which inter-individual variation in mRNA decay contributes to inter-individual variation in gene expression levels in humans. The study examines properties of genome-wide decay rates and the relationship between mRNA decay and gene expression across genes, across individual...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37451 | biostudies-arrayexpress
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